GOSR1

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Full Name
golgi SNAP receptor complex member 1
Function
Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
Biological Process
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
Intra-Golgi vesicle-mediated transport Source: ProtInc
Protein transport Source: UniProtKB-KW
Regulation of vesicle targeting, to, from or within Golgi Source: GO_Central
Retrograde transport, endosome to Golgi Source: HGNC-UCL
Vesicle fusion Source: GO_Central
Cellular Location
Golgi apparatus membrane. Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius).
Topology
Cytoplasmic: 2-229
Helical: 230-250
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Anti-GOSR1 antibodies

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Rabbit Anti-GOSR1 Recombinant Antibody (EG1348) (CBMAB-EN1626-LY)

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Target: GOSR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1348
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (CBLG1-1531) (CBMAB-G4394-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-1531
Application*: IC/IF, WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (CBLG1-1532) (CBMAB-G4395-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1532
Application*: E, WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (CBLG1-1530) (CBMAB-G4393-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLG1-1530
Application*: WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (CBLG1-1529) (CBMAB-G4392-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat, Mouse
Clone: CBLG1-1529
Application*: WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (HFD9-5) (CBMAB-G4391-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Cattle, Dog, Hamster, Mouse, Sheep, Pig, Rabbit
Clone: HFD9-5
Application*: IC, IF, IM, IP, WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (CBLG1-180) (CBMAB-G0633-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-180
Application*: E, WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (HFD9) (CBMAB-G0632-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse, Pig, Cattle, Dog, Chicken, Rabbit, Sheep
Clone: HFD9
Application*: WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (4E99) (CBMAB-G0631-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Cattle, Cat, Chicken, Human, Mouse, Pig, Rabbit, Sheep
Clone: 4E99
Application*: WB
Datasheet SDS

Mouse Anti-GOSR1 Recombinant Antibody (CBLG1-2888) (CBMAB-G0630-LY)

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Target: GOSR1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse, Human
Clone: CBLG1-2888
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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