GRAP2
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Full Name
GRB2-Related Adaptor Protein 2
Function
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
Biological Process
Cell-cell signaling Source: ProtInc
Ras protein signal transduction Source: ProtInc
Ras protein signal transduction Source: ProtInc
Cellular Location
Endosome; Nucleus; Cytoplasm
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Anti-GRAP2 antibodies
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Target: GRAP2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1429
Application*: WB: 1:500~1:1000 ELISA: 1:40000
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-1697
Application*: E, P, WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1694
Application*: WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-1693
Application*: WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: UW40
Application*: WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2939
Application*: WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5C7-F4-E7
Application*: WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G12
Application*: P, WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-216
Application*: E, IH, WB
Target: GRAP2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2984
Application*: WB
Target: GRAP2
Specificity: Human
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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