HSV-1 gC

HSV-1 glycoprotein C binds complement component C3b and inhibits the interaction of C5 and properdin (P) with C3b, blocking activation of both the classical and alternative complement pathways. HSV-1 gC prevents complement-mediated neutralization of cell-free virus, inhibits complement-mediated lysis of infected cells, and contributes to virulence in vivo, as viruses deficient in binding C3b or blocking C5 and P from interacting with C3b are more attenuated than wild-type virus in a murine flank model of infection.
Full Name
Herpes simplex virus 1 glycoprotein C
Function
Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions (By similarity).
Biological Process
Adhesion receptor-mediated virion attachment to host cell Source: UniProtKB-KW
Suppression by virus of host complement activation Source: UniProtKB-KW
Viral entry into host cell Source: UniProtKB-KW
Cellular Location
Virion membrane
Topology
Virion surface: 25-480
Helical: 481-497
Intravirion: 498-511
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Anti-HSV-1 gC antibodies

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Mouse Anti-HSV-1 gC Recombinant Antibody (CBMC-C1008) (CBMAB-V208-0206-CQ)

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Target: HSV-1 gC
Host: Mouse
Antibody Isotype: IgM
Specificity: HSV-1
Clone: CBMC-C1008
Application*: E
Datasheet SDS

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0910) (CBMAB-V208-1051-FY)

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Target: HSV-1 gC
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: HSV
Clone: CBMW-H0910
Application*: WB, IF
Datasheet SDS

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0909) (CBMAB-V208-1050-FY)

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Target: HSV-1 gC
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: HSV
Clone: CBMW-H0909
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0908) (CBMAB-V208-1049-FY)

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Target: HSV-1 gC
Host: Mouse
Antibody Isotype: IgG2b
Specificity: HSV
Clone: CBMW-H0908
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0907) (CBMAB-V208-1048-FY)

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Target: HSV-1 gC
Host: Mouse
Antibody Isotype: IgG2a
Specificity: HSV
Clone: CBMW-H0907
Application*: E, IF
Datasheet SDS

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0906) (CBMAB-V208-1047-FY)

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Target: HSV-1 gC
Host: Mouse
Antibody Isotype: IgG1
Specificity: HSV-1
Clone: CBMW-H0906
Application*: WB
Datasheet SDS

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0077) (CBMAB-V208-0087-FY)

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Target: HSV-1 gC
Host: Mouse
Antibody Isotype: IgG2
Specificity: HSV
Clone: CBMW-H0077
Application*: IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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