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Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0909) (CBMAB-V208-1050-FY)


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Summary

Host Animal
Mouse
Specificity
HSV
Clone
CBMW-H0909
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IF

Basic Information

Specificity
HSV
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Purity
>95% by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Herpes simplex virus 1 glycoprotein C
Introduction
HSV-1 glycoprotein C binds complement component C3b and inhibits the interaction of C5 and properdin (P) with C3b, blocking activation of both the classical and alternative complement pathways. HSV-1 gC prevents complement-mediated neutralization of cell-free virus, inhibits complement-mediated lysis of infected cells, and contributes to virulence in vivo, as viruses deficient in binding C3b or blocking C5 and P from interacting with C3b are more attenuated than wild-type virus in a murine flank model of infection.
Alternative Names
Herpes simplex virus 1 glycoprotein C; HSV-1 gC; HHV-1
Function
Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions (By similarity).
Biological Process
Adhesion receptor-mediated virion attachment to host cell Source: UniProtKB-KW
Suppression by virus of host complement activation Source: UniProtKB-KW
Viral entry into host cell Source: UniProtKB-KW
Cellular Location
Virion membrane
Topology
Virion surface: 25-480
Helical: 481-497
Intravirion: 498-511
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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