Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0908) (CBMAB-V208-1049-FY)

Name: Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0908)
SKU: CBMAB-V208-1049-FY
Rating: 5 (1 reviews)

See all HSV-1 gC antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBMW-H0908

Application

ELISA, ICC, WB

Immunogen

Extract of HSV-1 infected VERO (green monkey kidney) cells

Specificity

HSV

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Herpes simplex virus 1 glycoprotein C

Introduction

HSV-1 glycoprotein C binds complement component C3b and inhibits the interaction of C5 and properdin (P) with C3b, blocking activation of both the classical and alternative complement pathways. HSV-1 gC prevents complement-mediated neutralization of cell-free virus, inhibits complement-mediated lysis of infected cells, and contributes to virulence in vivo, as viruses deficient in binding C3b or blocking C5 and P from interacting with C3b are more attenuated than wild-type virus in a murine flank model of infection.

Alternative Names

Herpes simplex virus 1 glycoprotein C; HSV-1 gC; HHV-1

Function

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Plays also several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions (By similarity).

Biological Process

Adhesion receptor-mediated virion attachment to host cell Source: UniProtKB-KW
Suppression by virus of host complement activation Source: UniProtKB-KW
Viral entry into host cell Source: UniProtKB-KW

Cellular Location

Virion membrane

Topology

Virion surface: 25-480
Helical: 481-497
Intravirion: 498-511

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0908)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0906) (CAT#: CBMAB-V208-1047-FY)

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0907) (CAT#: CBMAB-V208-1048-FY)

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0909) (CAT#: CBMAB-V208-1050-FY)

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0910) (CAT#: CBMAB-V208-1051-FY)

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMW-H0077) (CAT#: CBMAB-V208-0087-FY)

Mouse Anti-HSV-1 gC Recombinant Antibody (CBMC-C1008) (CAT#: CBMAB-V208-0206-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry