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IER2

IER2 (Immediate Early Response 2) is a Protein Coding gene. An important paralog of this gene is IER5.

Full Name

immediate early response 2

Function

DNA-binding protein that seems to act as a transcription factor (PubMed:19584537).

Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity).

May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity).

Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713).

Biological Process

Cell motility Source: UniProtKB
Neuron differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Response to fibroblast growth factor Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus. Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.

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Anti-IER2 antibodies

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Mouse Anti-IER2 Recombinant Antibody (3E2) (CBMAB-A4234-LY)

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Target: IER2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3E2

Application*: WB, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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