IL9
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 9
Function
Supports IL-2 independent and IL-4 independent growth of helper T-cells.
Biological Process
B cell differentiationIEA:Ensembl
B cell proliferationIEA:Ensembl
Immunoglobulin mediated immune responseIEA:Ensembl
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-5 productionISS:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
B cell proliferationIEA:Ensembl
Immunoglobulin mediated immune responseIEA:Ensembl
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-5 productionISS:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Cellular Location
Secreted
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Anti-IL9 antibodies
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CompareTarget: IL9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 9C1
Application*: BL
Target: IL9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF243
Application*: ELISA, WB, IHC
Target: IL9
Sensitivity: 0.0098 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Il9
Sensitivity: 0.0052 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: IL9
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-144
Tag: His Tag
Target: IL9
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-144
Tag: His Tag
Target: IL9
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-144
Tag: His Tag
Target: IL9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A615
Application*: ICC, IHC, IP, WB
Target: IL9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A614
Application*: ELISA, IHC, WB
Target: IL9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C9
Application*: E, E
Target: IL9
Host: Rat
Specificity: Mouse
Clone: RM9A4
Application*: FN
Target: IL9
Host: Hamster
Antibody Isotype: IgG2, κ
Specificity: Mouse
Clone: D9302C12
Application*: FN
Target: IL9
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: D8402E8
Application*: E
Target: IL9
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 9D1
Application*: E
Target: IL9
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 9A4
Application*: E, F
Target: IL9
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1251
Application*: WB
Target: IL9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0740
Application*: N
Target: IL9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 623153
Application*: F, MC
Target: IL9
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0553
Application*: EC
Target: IL9
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0450
Application*: F, IS, E
Target: IL9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I0327
Application*: F
Target: IL9
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0326
Application*: F, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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