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Mouse Anti-IL9 Recombinant Antibody (CBYY-I0327) (CBMAB-I0863-YY)

This product is Mouse antibody that recognizes IL9. The antibody CBYY-I0327 can be used for immunoassay techniques such as: FC
See all IL9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0327
Antibody Isotype
IgG2a, κ
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin, 0.2% BSA, pH 7.2
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 9
Introduction
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
Entrez Gene ID
3578
UniProt ID
P15248
Alternative Names
Interleukin 9
Function
Supports IL-2 independent and IL-4 independent growth of helper T-cells.
Biological Process
B cell differentiationIEA:Ensembl
B cell proliferationIEA:Ensembl
Immunoglobulin mediated immune responseIEA:Ensembl
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-5 productionISS:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Cellular Location
Secreted

Kharwadkar, R., Ulrich, B. J., Chu, M., Koh, B., Hufford, M. M., Fu, Y., ... & Kaplan, M. H. (2023). ERG functionally overlaps with other Ets proteins in promoting TH9 cell expression of Il9 during allergic lung inflammation. The Journal of Immunology, 210(5), 537-546.

Sohn, J., Li, L., Zhang, L., Settem, R. P., Honma, K., Sharma, A., ... & Kirkwood, K. L. (2022). Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9‐producing CD4+ T cells. Molecular Oral Microbiology, 37(2), 42-52.

Zha, L., Dong, J., Chen, Q., Liao, Y., Zhang, H., Xie, T., ... & Nie, S. (2022). Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population. Cytokine, 150, 155761.

Chen, Q., Wang, W., Khanal, S., Han, J., Zhang, M., Chen, Y., ... & Wang, B. (2021). Transcriptome analysis reveals genes potentially related to high fiber strength in a Gossypium hirsutum line IL9 with Gossypium mustelinum introgression. Genome, 64(11), 985-995.

Sun, Y., Liu, S., Hu, R., Zhou, Q., & Li, X. (2020). Decreased placental IL9 and IL9R in preeclampsia impair trophoblast cell proliferation, invasion, and angiogenesis. Hypertension in Pregnancy, 39(3), 228-235.

Fu, Y., Wang, J., Panangipalli, G., Ulrich, B. J., Koh, B., Xu, C., ... & Kaplan, M. H. (2020). STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus. Nature communications, 11(1), 4882.

Lee, W. H., Jang, S. W., Kim, H. S., Kim, S. H., Heo, J. I., Kim, G. E., & Lee, G. R. (2019). BATF3 is sufficient for the induction of Il9 expression and can compensate for BATF during Th9 cell differentiation. Experimental & molecular medicine, 51(11), 1-12.

Abdul Qayum, A., Koh, B., Martin, R. K., Kenworthy, B. T., Kharwadkar, R., Fu, Y., ... & Kaplan, M. H. (2019). The Il9 CNS-25 regulatory element controls mast cell and basophil IL-9 production. The Journal of Immunology, 203(5), 1111-1121.

Li, L., Huang, S., Wang, H., Chao, K., Ding, L., Feng, R., ... & Zhang, S. (2018). Cytokine IL9 triggers the pathogenesis of inflammatory bowel disease through the miR21-CLDN8 pathway. Inflammatory Bowel Diseases, 24(10), 2211-2223.

Koh, B., Abdul Qayum, A., Srivastava, R., Fu, Y., Ulrich, B. J., Janga, S. C., & Kaplan, M. H. (2018). A conserved enhancer regulates Il9 expression in multiple lineages. Nature communications, 9(1), 4803.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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