JAML

JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid celland Cell surface interactions at the vascular wall.

Junction Adhesion Molecule Like

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Gamma-delta T cell activationISS:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Monocyte extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of epithelial cell proliferation involved in wound healingISS:UniProtKB

Cell membrane; Cell junction. Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

Extracellular: 20-275
Helical: 276-296
Cytoplasmic: 297-394