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Hamster Anti-JAML Recombinant Antibody (40000000000) (CBMAB-0198-WJ)

This product is a hamster antibody that recognizes JAML. The antibody 40000000000 can be used for immunoassay techniques such as: FC, WB.
See all JAML antibodies

Summary

Host Animal
Hamster
Specificity
Mouse
Clone
40000000000
Antibody Isotype
IgG
Application
FC, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Junction Adhesion Molecule Like
Introduction
JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Entrez Gene ID
270152
UniProt ID
Q80UL9
Alternative Names
AMICA; Gm638; AMICA1; CREA7-1; CREA7-4
Function
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Biological Process
Gamma-delta T cell activationISS:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Monocyte extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of epithelial cell proliferation involved in wound healingISS:UniProtKB
Cellular Location
Cell membrane; Cell junction. Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
Topology
Extracellular: 20-275
Helical: 276-296
Cytoplasmic: 297-394
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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