Mouse Anti-JAML Recombinant Antibody (CBWJJ-022) (CBMAB-0011-WJ)

Name: Mouse Anti-JAML Recombinant Antibody (CBWJJ-022)
SKU: CBMAB-0011-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJJ-022

Application

Immunogen

Recombinant Human JAML / AMICA1 protein.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Junction Adhesion Molecule Like

Introduction

JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Entrez Gene ID

120425

UniProt ID

Q86YT9

Alternative Names

AMICA; Gm638; AMICA1; CREA7-1; CREA7-4

Function

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Biological Process

Gamma-delta T cell activationISS:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Monocyte extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of epithelial cell proliferation involved in wound healingISS:UniProtKB

Cellular Location

Cell membrane; Cell junction. Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

Topology

Extracellular: 20-275
Helical: 276-296
Cytoplasmic: 297-394

Wu, Q., Wang, Y. B., Che, X. W., Wang, H., & Wang, W. (2023). Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma. Journal of Integrative Medicine, 21(3), 268-276.

Wu, Q., Li, R., Wang, Q. X., Zhang, M. Y., Liu, T. T., & Qu, Y. Q. (2022). Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/β-catenin signaling pathway in lung adenocarcinoma. Journal of Translational Medicine, 20(1), 1-17.

Fang, Y., Yang, J., Zu, G., Cong, C., Liu, S., Xue, F., ... & Sun, M. (2021). Junctional adhesion molecule-like protein promotes tumor progression and metastasis via p38 signaling pathway in gastric cancer. Frontiers in Oncology, 11, 565676.

Sun, Y., Guan, J., Hou, Y., Xue, F., Huang, W., Zhang, W., ... & Yang, J. (2019). Silencing of junctional adhesion molecule-like protein attenuates atherogenesis and enhances plaque stability in apoe−/− mice. Clinical Science, 133(11), 1215-1228.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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