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Mouse Anti-JAML Recombinant Antibody (CBYC-A990) (CBMAB-A4527-YC)

Provided herein is a Mouse monoclonal antibody against Human junction adhesion molecule like. The antibody can be used for immunoassay techniques, such as FC.
See all JAML antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-A990
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Junction Adhesion Molecule Like
Introduction
JAML has broad expression in appendix (RPKM 34.6), spleen (RPKM 24.5) and 14 other tissues.
Entrez Gene ID
120425
UniProt ID
Q86YT9
Alternative Names
AMICA; Gm638; AMICA1; CREA7-1; CREA7-4
Function
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Biological Process
Gamma-delta T cell activationISS:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIDA:UniProtKB
Monocyte extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil chemotaxisManual Assertion Based On ExperimentIMP:UniProtKB
Neutrophil extravasationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of epithelial cell proliferation involved in wound healingISS:UniProtKB
Cellular Location
Cell membrane; Cell junction. Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
Topology
Extracellular: 20-275
Helical: 276-296
Cytoplasmic: 297-394
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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