MCF2L

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants.

MCF.2 cell line derived transforming sequence-like

Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity).

Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity).

Isoform 5 activates CDC42 (PubMed:15157669).

Isoform 3:
Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669).

Intracellular signal transduction Source: InterPro
Positive regulation of Rho protein signal transduction Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome

Isoform 5:
Plasma membrane
Cell membrane
Cytoplasm
Isoform 3:
Cytoplasm
Other locations
Endomembrane system
Note: Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain.
Plasma membrane
Cell membrane
Cytoplasm