MCF2L

This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants.
Full Name
MCF.2 cell line derived transforming sequence-like
Function
Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity).

Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity).

Isoform 5 activates CDC42 (PubMed:15157669).

Isoform 3:
Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669).
Biological Process
Intracellular signal transduction Source: InterPro
Positive regulation of Rho protein signal transduction Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Isoform 5:
Plasma membrane
Cell membrane
Cytoplasm
Isoform 3:
Cytoplasm
Other locations
Endomembrane system
Note: Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain.
Plasma membrane
Cell membrane
Cytoplasm
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Anti-MCF2L antibodies

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Mouse Anti-MCF2L Recombinant Antibody (1D11) (CBMAB-A5340-LY)

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Target: MCF2L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D11
Application*: WB, E
Datasheet SDS

Mouse Anti-MCF2L Recombinant Antibody (CBFYM-1868) (CBMAB-M2039-FY)

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Target: MCF2L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1868
Application*: E, WB, P
Datasheet SDS

Mouse Anti-MCF2L (AA 220-320) Recombinant Antibody (CBFYM-0789) (CBMAB-M0933-FY)

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Target: MCF2L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0789
Application*: E, P, WB
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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