MED15

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Full Name
mediator complex subunit 15
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
Biological Process
Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Stem cell population maintenance Source: Ensembl
Cellular Location
Nucleus
Cytoplasm
PTM
Ubiquitinated by TRIM11, leading to proteasomal degradation.
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Anti-MED15 antibodies

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Mouse Anti-MED15 Recombinant Antibody (CBYC-P102) (CBMAB-P0501-YC)

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Target: MED15
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC-P102
Application*: WB
Datasheet SDS

Mouse Anti-MED15 Recombinant Antibody (6F4) (CBMAB-BR349LY)

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Target: MED15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F4
Application*: FC, IF, ICC, WB
Datasheet SDS

Mouse Anti-MED15 Recombinant Antibody (4A4) (CBMAB-A6476-LY)

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Target: MED15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A4
Application*: WB, E
Datasheet SDS

Mouse Anti-MED15 (AA 393-679 ) Recombinant Antibody (CBFYM-1997) (CBMAB-M2175-FY)

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Target: MED15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1997
Application*: WB, IH
Datasheet SDS

Mouse Anti-MED15 (AA 1-89) Recombinant Antibody (CBFYM-0502) (CBMAB-M0630-FY)

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Target: MED15
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0502
Application*: E, IC, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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