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MED15

The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Full Name

mediator complex subunit 15

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.

Biological Process

Positive regulation of transcription elongation from RNA polymerase II promoter Source: ComplexPortal
Positive regulation of transcription initiation from RNA polymerase II promoter Source: ComplexPortal
RNA polymerase II preinitiation complex assembly Source: ComplexPortal
Stem cell population maintenance Source: Ensembl

Cellular Location

Nucleus
Cytoplasm

PTM

Ubiquitinated by TRIM11, leading to proteasomal degradation.

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Anti-MED15 antibodies

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Mouse Anti-MED15 Recombinant Antibody (CBYC-P102) (CBMAB-P0501-YC)

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Target: MED15

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYC-P102

Application*: WB

Mouse Anti-MED15 Recombinant Antibody (6F4) (CBMAB-BR349LY)

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Target: MED15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6F4

Application*: FC, IF, ICC, WB

Mouse Anti-MED15 Recombinant Antibody (4A4) (CBMAB-A6476-LY)

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Target: MED15

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4A4

Application*: WB, E

Mouse Anti-MED15 (AA 393-679 ) Recombinant Antibody (CBFYM-1997) (CBMAB-M2175-FY)

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Target: MED15

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-1997

Application*: WB, IH

Mouse Anti-MED15 (AA 1-89) Recombinant Antibody (CBFYM-0502) (CBMAB-M0630-FY)

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Target: MED15

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYM-0502

Application*: E, IC, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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