MELTF
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Full Name
Melanotransferrin
Function
Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
Biological Process
Iron ion homeostasis Source: UniProtKB-KW
Iron ion transport Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of plasminogen activation Source: UniProtKB
Iron ion transport Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of plasminogen activation Source: UniProtKB
Cellular Location
Cell membrane
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Anti-MELTF antibodies
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CompareTarget: MELTF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 214D4
Application*: P, C
Target: MELTF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SHM72
Application*: F
Target: MELTF
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0921
Application*: F
Target: MELTF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2947
Application*: P, C
Target: MELTF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYM-2060
Application*: E, WB
Target: MELTF
Host: Rabbit
Specificity: Human
Clone: CBFYM-2059
Application*: IH
Target: MELTF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-2058
Application*: WB
Target: MELTF
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYM-2057
Application*: WB, E, F
Target: MELTF
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBFYM-2056
Application*: E, WB
Target: MELTF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2055
Application*: WB
Target: MELTF
Host: Rabbit
Specificity: Human
Clone: CBFYM-2054
Application*: WB
Target: MELTF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-0455
Application*: E, WB
Target: MELTF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0218
Application*: F
Target: MELTF
Sensitivity: 0.024 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: MELTF
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-708
Tag: His Tag
Target: MELTF
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-708
Tag: His Tag
Target: MELTF
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-708
Tag: hFc Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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