MELTF

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]

Full Name

Melanotransferrin

Function

Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.

Biological Process

Iron ion homeostasis Source: UniProtKB-KW
Iron ion transport Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Positive regulation of extracellular matrix disassembly Source: UniProtKB
Positive regulation of plasminogen activation Source: UniProtKB

Cellular Location

Cell membrane

Anti-MELTF antibodies

Human Anti-MELTF Recombinant Antibody (CBXC-0921) (CBMAB-C2036-CQ)

Datasheet

SDS

Target: MELTF

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0921

Application*: F

Mouse Anti-MELTF Recombinant Antibody (CBFYC-2947) (CBMAB-C3023-FY)

Datasheet

SDS

Target: MELTF

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2947

Application*: P, C

Rabbit Anti-MELTF Recombinant Antibody (CBFYM-2060) (CBMAB-M2241-FY)

Datasheet

SDS

Target: MELTF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBFYM-2060

Application*: E, WB

Datasheet

SDS

Target: MELTF

Host: Rabbit

Specificity: Human

Clone: CBFYM-2054

Application*: WB

Rabbit Anti-MELTF (AA 627-655) Recombinant Antibody (CBFYM-0455) (CBMAB-M0573-FY)

Datasheet

SDS

Target: MELTF

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYM-0455

Application*: E, WB

Mouse Anti-MELTF (AA 1-711) Recombinant Antibody (CBFYM-0218) (CBMAB-M0261-FY)

Datasheet

SDS

Target: MELTF

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYM-0218

Application*: F

Mouse Anti-MELTF Recombinant Antibody (SHM72) (CBMAB-C12048-LY)

Datasheet

SDS

Target: MELTF

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: SHM72

Application*: F

Mouse Anti-MELTF Recombinant Antibody (214D4) (CBMAB-C4383-LY)

Datasheet

SDS

Target: MELTF

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 214D4

Application*: P, C

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)