MRPL58

The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Full Name
Mitochondrial Ribosomal Protein L58
Function
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
Biological Process
Mitochondrial translation Source: ComplexPortal
Mitochondrial translational termination Source: UniProtKB
Cellular Location
Mitochondrion
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Anti-MRPL58 antibodies

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Mouse Anti-MRPL58 Recombinant Antibody (A1178) (CBMAB-AP3552LY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A1178
Application*: Dot blot, ELISA, WB
Datasheet SDS

Mouse Anti-MRPL58 Recombinant Antibody (6F8) (CBMAB-A4200-LY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6F8
Application*: SE, E
Datasheet SDS

Mouse Anti-MRPL58 Recombinant Antibody (4C10) (CBMAB-A4199-LY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C10
Application*: WB, E
Datasheet SDS

Mouse Anti-MRPL58 Recombinant Antibody (CBYY-I1994) (CBMAB-I3164-YY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1994
Application*: WB, IH
Datasheet SDS

Mouse Anti-MRPL58 Recombinant Antibody (CBYY-I1198) (CBMAB-I2367-YY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I1198
Application*: E, WB
Datasheet SDS

Mouse Anti-MRPL58 Recombinant Antibody (AT1E9) (CBMAB-I1921-YY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT1E9
Application*: C, E, WB
Datasheet SDS

Mouse Anti-MRPL58 Recombinant Antibody (2456C1a) (CBMAB-I0136-YY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2456C1a
Application*: IC, WB, P, DB
Datasheet SDS

Mouse Anti-MRPL58 Recombinant Antibody (CBYY-I0053) (CBMAB-I0135-YY)

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Target: MRPL58
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0053
Application*: WB, F, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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