MTDH

MTDH (Metadherin) is a Protein Coding gene. Diseases associated with MTDH include Gallbladder Adenocarcinoma and Nervous System Disease. Among its related pathways are Validated targets of C-MYC transcriptional activation and Gastric Cancer Network 2. Gene Ontology (GO) annotations related to this gene include double-stranded RNA binding.
Full Name
Metadherin
Function
Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Biological Process
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of angiogenesis Source: UniProtKB
Positive regulation of autophagy Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
Positive regulation of protein kinase B signaling Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Nucleus membrane
nucleolus
Endoplasmic reticulum
Endoplasmic reticulum membrane
Other locations
tight junction
perinuclear region
Note: In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF-alpha causes translocation from the cytoplasm to the nucleus.
Topology
Lumenal: 1-48
Helical: 49-69
Cytoplasmic: 70-582
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Anti-MTDH antibodies

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Mouse Anti-MTDH Recombinant Antibody (IHC507) (CBMAB-MA170-YC)

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Target: MTDH
Host: Mouse
Specificity: Human
Clone: IHC507
Application*: P, E, IH
Datasheet SDS

Rabbit Anti-MTDH (Phosphorylated S568) Recombinant Antibody (PTM-CBMAB-0976LY)

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Target: MTDH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: WB, P, PE
Datasheet SDS

Rabbit Anti-MTDH (AA 561-570) Recombinant Antibody (CBFYM-2729) (CBMAB-M2922-FY)

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Target: MTDH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBFYM-2729
Application*: F, IC, IF, P, WB
Datasheet SDS

Mouse Anti-MTDH (AA 70-582) Recombinant Antibody (CBFYM-2728) (CBMAB-M2921-FY)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2728
Application*: P
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBFYM-2727) (CBMAB-M2920-FY)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2727
Application*: E, F, IH, WB
Datasheet SDS

Rat Anti-Mtdh Recombinant Antibody (CBYJL-2415) (CBMAB-L2741-YJ)

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Target: Mtdh
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJL-2415
Application*: WB
Datasheet SDS

Rabbit Anti-MTDH Recombinant Antibody (CBYJL-255) (CBMAB-L0358-YJ)

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Target: MTDH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-255
Application*: IC, IF
Datasheet SDS

Rabbit Anti-MTDH Recombinant Antibody (CBYJL-254) (CBMAB-L0357-YJ)

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Target: MTDH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJL-254
Application*: WB, P
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBYJL-252) (CBMAB-L0355-YJ)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-252
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (2F11C3) (CBMAB-L0354-YJ)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F11C3
Application*: WB, F, E, IH, P
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBYJL-251) (CBMAB-L0353-YJ)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-251
Application*: WB, IH
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBYC3-102) (CBMAB-1793-YC)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC3-102
Application*: E, F, P, WB
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBT903) (V2LY-0625-LY3185)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT903
Application*: WB, P, IF, F, E
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBT4538) (V2LY-0625-LY2372)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4538
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBT3545) (V2LY-0625-LY1910)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBT3545
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-MTDH Recombinant Antibody (CBT2855) (V2LY-0625-LY1909)

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Target: MTDH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBT2855
Application*: WB, IH, IC, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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