NCF1

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

Full Name

Neutrophil Cytosolic Factor 1

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Biological Process

Apoptotic process Source: Ensembl
Cellular defense response Source: ProtInc
Cellular response to cadmium ion Source: CAFA
Cellular response to reactive oxygen species Source: CAFA
Innate immune response Source: BHF-UCL
Positive regulation of epidermal growth factor-activated receptor activity Source: CAFA
Positive regulation of JNK cascade Source: CAFA
Positive regulation of p38MAPK cascade Source: CAFA
Positive regulation of phosphatidylinositol 3-kinase signaling Source: CAFA
Positive regulation of transcription, DNA-templated Source: CAFA
Protein targeting to membrane Source: UniProtKB
Reactive oxygen species biosynthetic process Source: Ensembl
Regulation of respiratory burst involved in inflammatory response Source: Ensembl
Respiratory burst Source: GO_Central
Superoxide anion generation Source: GO_Central
Superoxide metabolic process Source: BHF-UCL

Cellular Location

Cytosol
Other locations
Membrane

Involvement in disease

Granulomatous disease, chronic, autosomal recessive, 1 (CGD1):
A form of chronic granulomatous disease, a primary immunodeficiency characterized by severe recurrent bacterial and fungal infections, along with manifestations of chronic granulomatous inflammation. It results from an impaired ability of phagocytes to mount a burst of reactive oxygen species in response to pathogens.

PTM

Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity.