NEDD1

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Full Name

neural precursor cell expressed, developmentally down-regulated 1

Function

Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Protein localization to centrosome Source: GO_Central

Cellular Location

Centrosome

PTM

During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation.

Anti-NEDD1 antibodies

Mouse Anti-NEDD1 Recombinant Antibody (H-3) (CBMAB-N1747-WJ)

Datasheet

SDS

Target: NEDD1

Host: Mouse

Specificity: Human

Clone: H-3

Application*: WB, IP, IF, E

Mouse Anti-NEDD1 Recombinant Antibody (7D10) (CBMAB-N1746-WJ)

Datasheet

SDS

Target: NEDD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: 7D10

Application*: E, IH, WB

Mouse Anti-NEDD1 Recombinant Antibody (3H7) (CBMAB-N1745-WJ)

Datasheet

SDS

Target: NEDD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3H7

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)