OGA

Full Name
O-GlcNAcase
Function
Isoform 1
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210).
Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
Isoform 3
Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
Biological Process
Isoform 3
Nucleus
Isoform 1
Cytoplasm
PTM
Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
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Anti-OGA antibodies

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Mouse Anti-OGA Recombinant Antibody (A1080) (CBMAB-AP11813LY)

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Target: OGA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1080
Application*: ELISA, IF, IHC, WB
Datasheet SDS

Mouse Anti-OGA Recombinant Antibody (CF286) (CBMAB-FT212LY)

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Target: OGA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF286
Application*: ELISA, WB, IF, IHC
Datasheet SDS

Rabbit Anti-OGA Recombinant Antibody (CBFYM-2176) (CBMAB-M2358-FY)

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Target: OGA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBFYM-2176
Application*: WB, IP, P
Datasheet SDS

Mouse Anti-OGA (AA 823-916) Recombinant Antibody (CBFYM-2175) (CBMAB-M2357-FY)

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Target: OGA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2175
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-OGA Recombinant Antibody (CBFYM-2174) (CBMAB-M2356-FY)

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Target: OGA
Host: Mouse
Specificity: Human
Clone: CBFYM-2174
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-OGA Recombinant Antibody (CBFYM-0633) (CBMAB-M0768-FY)

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Target: OGA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-0633
Application*: E, WB
Datasheet SDS

Rabbit Anti-OGA Recombinant Antibody (
8D12) (V2LY-0725-LY1400)

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Target: OGA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 8D12
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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