OTOA

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

otoancorin

May act as an adhesion molecule.

Cell-matrix adhesionManual Assertion Based On ExperimentIBA:GO_Central
Sensory perception of soundIEA:UniProtKB-KW
Transmission of nerve impulseIEA:Ensembl

Apical cell membrane
Secreted, extracellular space, extracellular matrix
At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.

Deafness, autosomal recessive, 22 (DFNB22):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.