PARP14

PARP14 is a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types.

Full Name

Poly(ADP-Ribose) Polymerase Family Member 14

Function

ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins (PubMed:16061477, PubMed:27796300, PubMed:18851833, PubMed:25043379).
In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:25043379).
Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation (PubMed:27796300).
However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703' (PubMed:29858569).
Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription (PubMed:27796300).
In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation (PubMed:27796300).
Mono-ADP-ribosylates PARP9 (PubMed:27796300).

Biological Process

Innate immune responseIEA:UniProtKB-KW
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of interferon-gamma-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of interleukin-4-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIMP:UniProtKB
Protein ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein mono-ADP-ribosylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein poly-ADP-ribosylationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Cytoplasm
In steady state splenocytes the protein is mostly nuclear (By similarity).
A minor proportion is detected in the cytoplasm (By similarity).
In macrophages, mainly localizes to the cytoplasm (PubMed:27796300).

PTM

Auto-ADP-ribosylated.