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POLE2

DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency.

Full Name

polymerase (DNA directed), epsilon 2 (p59 subunit)

Function

Accessory component of the DNA polymerase epsilon complex (PubMed:10801849).
Participates in DNA repair and in chromosomal DNA replication (By similarity).

Biological Process

DNA repairManual Assertion Based On ExperimentTAS:ProtInc
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Error-prone translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

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Anti-POLE2 antibodies

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Mouse Anti-POLE2 Recombinant Antibody (CBYCD-494) (CBMAB-D2182-YC)

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Target: POLE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCD-494

Application*: WB, F

Mouse Anti-POLE2 Recombinant Antibody (CBYC-P497) (CBMAB-P2323-YC)

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Target: POLE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P497

Application*: E, WB

Mouse Anti-POLE2 Recombinant Antibody (1A3) (CBMAB-P2322-YC)

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Target: POLE2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A3

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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