POLE2

DNA polymerase epsilon, which is involved in DNA repair and replication, is composed of a large catalytic subunit and a small accessory subunit. The protein encoded by this gene represents the small subunit (B). Defects in this gene have been linked to colorectal cancer and to combined immunodeficiency.

Full Name

polymerase (DNA directed), epsilon 2 (p59 subunit)

Function

Accessory component of the DNA polymerase epsilon complex (PubMed:10801849).
Participates in DNA repair and in chromosomal DNA replication (By similarity).

Biological Process

DNA repairManual Assertion Based On ExperimentTAS:ProtInc
DNA replicationManual Assertion Based On ExperimentTAS:ProtInc
DNA-templated DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Error-prone translesion synthesisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Anti-POLE2 antibodies

Mouse Anti-POLE2 Recombinant Antibody (CBYCD-494) (CBMAB-D2182-YC)

Datasheet

SDS

Target: POLE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYCD-494

Application*: WB, F

Mouse Anti-POLE2 Recombinant Antibody (CBYC-P497) (CBMAB-P2323-YC)

Datasheet

SDS

Target: POLE2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P497

Application*: E, WB

Mouse Anti-POLE2 Recombinant Antibody (1A3) (CBMAB-P2322-YC)

Datasheet

SDS

Target: POLE2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A3

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)