PPP1R14A

PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase (see MIM 603768). Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration.[supplied by OMIM

Full Name

protein phosphatase 1, regulatory (inhibitor) subunit 14A

Function

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Biological Process

Regulation of phosphorylationIEA:InterPro

Cellular Location

Cytoplasm

Anti-PPP1R14A antibodies

Mouse Anti-PPP1R14A Recombinant Antibody (16C84) (CBMAB-P2599-YC)

Datasheet

SDS

Target: PPP1R14A

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 16C84

Application*: E, WB

Mouse Anti-PPP1R14A Recombinant Antibody (CBXC-2564) (CBMAB-C0239-CQ)

Datasheet

SDS

Target: PPP1R14A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-2564

Application*: WB, E

Mouse Anti-PPP1R14A Recombinant Antibody (3A7) (CBMAB-A6964-LY)

Datasheet

SDS

Target: PPP1R14A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3A7

Application*: WB, E

Mouse Anti-PPP1R14A Recombinant Antibody (4H10) (CBMAB-C0959-YY)

Datasheet

SDS

Target: PPP1R14A

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4H10

Application*: E, F, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)