RASGEF1A

RASGEF1A (RasGEF Domain Family Member 1A) is a Protein Coding gene. Diseases associated with RASGEF1A include Intrahepatic Cholangiocarcinoma and Cholangiocarcinoma. Among its related pathways are RET signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and Ras guanyl-nucleotide exchange factor activity. An important paralog of this gene is RASGEF1B.

Full Name

RasGEF Domain Family Member 1A

Function

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.

Biological Process

Biological Process cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of Ras protein signal transductionManual Assertion Based On ExperimentIDA:FlyBase
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

cytosol
plasma membrane