SCIMP

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synapse formation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

SLP Adaptor And CSK Interacting Membrane Protein

Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792).
It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (PubMed:21930792).
In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity).
It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity).

Biological Process cellular response to molecule of fungal originISS:UniProtKB
Biological Process positive regulation of cytokine production involved in immune responseISS:UniProtKB
Biological Process positive regulation of dendritic cell cytokine productionISS:UniProtKB
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of interleukin-12 productionISS:UniProtKB
Biological Process positive regulation of interleukin-6 productionISS:UniProtKB
Biological Process positive regulation of lipopolysaccharide-mediated signaling pathwayISS:UniProtKB
Biological Process positive regulation of stress-activated MAPK cascadeISS:UniProtKB
Biological Process toll-like receptor 3 signaling pathwayISS:UniProtKB
Biological Process toll-like receptor 4 signaling pathwayISS:UniProtKB
Biological Process toll-like receptor 7 signaling pathwayISS:UniProtKB
Biological Process toll-like receptor TLR1:TLR2 signaling pathwayISS:UniProtKB

Cell membrane
Cytoplasmic vesicle, phagosome
Cell projection, ruffle
Cell projection, filopodium
Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs) (PubMed:21930792).
Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells (PubMed:21930792).
Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod (PubMed:21930792).
Present at regions of cell-cell contacts but also at the leading edge of migrating cells (PubMed:21930792).
Localizes to phagosomes in dendritic cells after exposure to particulate beta-glucan (By similarity).

Helical: 19-39

Phosphorylated by the Src-family protein tyrosine kinases LYN and SRC (PubMed:21930792).
Phosphorylation occurs on tyrosine residues upon MHC-II stimulation (PubMed:21930792).
Phosphorylation also occurs on tyrosine residues after activation of CLEC7A/DECTIN1 by particulate beta-glucan (By similarity).
Lipopolysaccharide (LPS) induces phosphorylation of Tyr-69, Tyr-107 and Tyr-131 differentially to allow temporal recruitment of effector proteins GRB2, CSK and BLNK (By similarity).
Phosphorylation of Tyr-69 is immediately induced by LPS stimulation and allows GRB2 to bind (By similarity).
Tyr-107 is phosphorylated 5 minutes after LPS stimulation, which then allows CSK to bind, followed by phosphorylation of Tyr-131 10 minutes after LPS induction, which allows BLNK to bind (By similarity).
Phosphorylation at Tyr-107 by LYN occurs after activation of TLR4 by lipopolysaccharide; phosphorylation enhances binding to TLR4 (By similarity).
Palmitoylated.