SLC2A3

Glucose transporter 3, also known as solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) is a protein that in humans is encoded by the SLC2A3gene. GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT. GLUT3 has been studied in other cell types with specific glucose requirements, including sperm, preimplantation embryos, circulating white blood cells and carcinoma cell lines.

Full Name

Solute Carrier Family 2 Member 3

Function

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916).
Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916).
Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).

Biological Process

Biological Process carbohydrate metabolic process1 PublicationNAS:ProtInc
Biological Process dehydroascorbic acid transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process galactose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process glucose importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glucose import across plasma membraneManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-ascorbic acid metabolic processTAS:Reactome
Biological Process monosaccharide transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrierManual Assertion Based On ExperimentIGI:ARUK-UCL

Cellular Location

Cell membrane
Perikaryon
Cell projection
Localized to densely spaced patches along neuronal processes.