SLC30A3

SLC30A3(solute carrier family 30 member 3) is a protein coding gene

Full Name

Solute Carrier Family 30 Member 3

Function

Zinc ion transporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain.

Biological Process

Biological Process positive regulation of transportIEA:Ensembl
Biological Process regulation of sequestering of zinc ionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process response to zinc ionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion import into synaptic vesicleIEA:Ensembl
Biological Process zinc ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Late endosome membrane
Lysosome membrane

Involvement in disease

Homodimerization through dityrosine bonds is stimulated by oxidative stress.

Topology

Cytoplasmic: 1-75
Helical: 76-96
Lumenal: 97-105
Helical: 106-126
Cytoplasmic: 127-145
Helical: 146-166
Lumenal: 167-177
Helical: 178-198
Cytoplasmic: 199-235
Helical: 236-256
Lumenal: 257-264
Helical: 265-285
Cytoplasmic: 286-388