SNPH
Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. [provided by RefSeq]
Full Name
syntaphilin
Function
Inhibits SNARE complex formation by absorbing free syntaxin-1.
Biological Process
Biological Process neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter secretion1 PublicationNAS:UniProtKB
Biological Process synaptic vesicle docking1 PublicationNAS:UniProtKB
Biological Process neurotransmitter secretion1 PublicationNAS:UniProtKB
Biological Process synaptic vesicle docking1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Synapse, synaptosome
Synapse, synaptosome
Topology
Helical: 425-444
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Anti-SNPH antibodies
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Target: SNPH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B6
Application*: WB, E
Target: SNPH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1371
Application*: WB, P
Target: SNPH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: CBXS-5516
Application*: WB, E
Target: SNPH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4777
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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