SRM
The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq]
Full Name
spermidine synthase
Function
Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.
Biological Process
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process polyamine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process polyamine metabolic processTAS:Reactome
Biological Process spermidine biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process polyamine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process polyamine metabolic processTAS:Reactome
Biological Process spermidine biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytosol
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Anti-SRM antibodies
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Target: SRM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2C1
Application*: SE, E
Target: SRM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2800
Application*: E, WB
Target: SRM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4422
Application*: E
Target: SRM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5777
Application*: IC, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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