SRM

The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq]

spermidine synthase

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.

Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process polyamine biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process polyamine metabolic processTAS:Reactome
Biological Process spermidine biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cytosol