THAP11

The protein encoded by this gene contains a THAP domain, which is a conserved DNA-binding domain that has striking similarity to the site-specific DNA-binding domain (DBD) of Drosophila P element transposases. [provided by RefSeq, Jul 2008]

THAP11 Gene(Protein Coding) THAP Domain Containing 11

Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).

Biological Process cell population proliferationSource:Ensembl
Biological Process electron transport chainSource:Ensembl
Biological Process negative regulation of neuron apoptotic processSource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:NTNU_SB1 Publication
Biological Process neuron differentiationSource:Ensembl
Biological Process positive regulation of androgen receptor activitySource:Ensembl
Biological Process regulation of mitochondrial transcriptionSource:Ensembl
Biological Process regulation of transcription by RNA polymerase IISource:GO_Central1 Publication

Nucleus
Cytoplasm
May be regulated by shuttling of the protein between the cytoplasm and nucleus.