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TNF

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Full Name
TNF Gene(Protein Coding) Tumor Necrosis Factor
Function
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208).
Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).
Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819).
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic processSource:UniProtKB1 Publication
Biological Process acute inflammatory responseSource:Ensembl
Biological Process astrocyte activationSource:ARUK-UCL1 Publication
Biological Process calcium-mediated signalingSource:Ensembl
Biological Process cellular response to amino acid stimulusSource:Ensembl
Biological Process cellular response to amyloid-betaSource:Ensembl
Biological Process cellular response to interferon-gammaSource:Ensembl
Biological Process cellular response to nicotineSource:UniProtKB1 Publication
Biological Process cellular response to organic cyclic compoundSource:UniProtKB1 Publication
Biological Process cellular response to retinoic acidSource:Ensembl
Biological Process cellular response to toxic substanceSource:Ensembl
Biological Process chronic inflammatory response to antigenic stimulusSource:BHF-UCL1 Publication
Biological Process circadian rhythmSource:Ensembl
Biological Process cognitionSource:ARUK-UCL1 Publication
Biological Process cortical actin cytoskeleton organizationSource:UniProtKB1 Publication
Biological Process defense response to Gram-positive bacteriumSource:Ensembl
Biological Process detection of mechanical stimulus involved in sensory perception of painSource:Ensembl
Biological Process embryonic digestive tract developmentSource:DFLAT1 Publication
Biological Process endothelial cell apoptotic processSource:Ensembl
Biological Process epithelial cell proliferation involved in salivary gland morphogenesisSource:Ensembl
Biological Process extracellular matrix organizationSource:Ensembl
Biological Process extrinsic apoptotic signaling pathwaySource:UniProtKB2 Publications
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:UniProtKB1 Publication
Biological Process glucose metabolic processSource:Ensembl
Biological Process humoral immune responseSource:Ensembl
Biological Process I-kappaB kinase/NF-kappaB signalingSource:Ensembl
Biological Process inflammatory responseSource:UniProtKB1 Publication
Biological Process intrinsic apoptotic signaling pathway in response to DNA damageSource:Ensembl
Biological Process JNK cascadeSource:Ensembl
Biological Process leukocyte migration involved in inflammatory responseSource:Ensembl
Biological Process leukocyte tethering or rollingSource:BHF-UCL1 Publication
Biological Process lipopolysaccharide-mediated signaling pathwaySource:UniProtKB1 Publication
Biological Process liver regenerationSource:Ensembl
Biological Process MAPK cascadeSource:UniProtKB1 Publication
Biological Process microglial cell activationSource:ARUK-UCL
Biological Process necroptotic signaling pathwaySource:UniProtKB3 Publications
Biological Process negative regulation of alkaline phosphatase activitySource:Ensembl
Biological Process negative regulation of amyloid-beta clearanceSource:ARUK-UCL
Biological Process negative regulation of apoptotic signaling pathwaySource:ARUK-UCL1 Publication
Biological Process negative regulation of bicellular tight junction assemblySource:UniProtKB1 Publication
Biological Process negative regulation of bile acid secretionSource:Ensembl
Biological Process negative regulation of blood vessel endothelial cell migrationSource:BHF-UCL1 Publication
Biological Process negative regulation of branching involved in lung morphogenesisSource:UniProtKB1 Publication
Biological Process negative regulation of cysteine-type endopeptidase activity involved in apoptotic processSource:ARUK-UCL1 Publication
Biological Process negative regulation of cytokine production involved in immune responseSource:BHF-UCL1 Publication
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB2 Publications
Biological Process negative regulation of endothelial cell proliferationSource:Ensembl
Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligandSource:BHF-UCL2 Publications
Biological Process negative regulation of fat cell differentiationSource:BHF-UCL1 Publication
Biological Process negative regulation of gene expressionSource:UniProtKB1 Publication
Biological Process negative regulation of glucose importSource:Ensembl
Biological Process negative regulation of heart rateSource:Ensembl
Biological Process negative regulation of interleukin-6 productionSource:BHF-UCL1 Publication
Biological Process negative regulation of L-glutamate import across plasma membraneSource:Ensembl
Biological Process negative regulation of lipid catabolic processSource:BHF-UCL1 Publication
Biological Process negative regulation of lipid storageSource:BHF-UCL1 Publication
Biological Process negative regulation of miRNA maturationSource:ARUK-UCL2 Publications
Biological Process negative regulation of mitotic cell cycleSource:Ensembl
Biological Process negative regulation of myelinationSource:Ensembl
Biological Process negative regulation of myoblast differentiationSource:Ensembl
Biological Process negative regulation of myosin-light-chain-phosphatase activitySource:UniProtKB1 Publication
Biological Process negative regulation of neurogenesisSource:ARUK-UCL1 Publication
Biological Process negative regulation of osteoblast differentiationSource:Ensembl
Biological Process negative regulation of oxidative phosphorylationSource:Ensembl
Biological Process negative regulation of protein-containing complex disassemblySource:UniProtKB1 Publication
Biological Process negative regulation of signaling receptor activitySource:BHF-UCL1 Publication
Biological Process negative regulation of systemic arterial blood pressureSource:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IISource:UniProtKB1 Publication
Biological Process negative regulation of vascular wound healingSource:BHF-UCL1 Publication
Biological Process negative regulation of viral genome replicationSource:BHF-UCL1 Publication
Biological Process osteoclast differentiationSource:Ensembl
Biological Process positive regulation of action potentialSource:Ensembl
Biological Process positive regulation of amyloid-beta formationSource:ARUK-UCL
Biological Process positive regulation of apoptotic processSource:UniProtKB3 Publications
Biological Process positive regulation of blood microparticle formationSource:BHF-UCL1 Publication
Biological Process positive regulation of calcidiol 1-monooxygenase activitySource:BHF-UCL1 Publication
Biological Process positive regulation of calcineurin-NFAT signaling cascadeSource:MGI1 Publication
Biological Process positive regulation of cell adhesionSource:UniProtKB1 Publication
Biological Process positive regulation of chemokine (C-X-C motif) ligand 2 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of chemokine productionSource:BHF-UCL1 Publication
Biological Process positive regulation of chronic inflammatory response to antigenic stimulusSource:Ensembl
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic processSource:UniProtKB1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosisSource:Ensembl
Biological Process positive regulation of cytokine productionSource:BHF-UCL2 Publications
Biological Process positive regulation of cytokine production involved in inflammatory responseSource:ARUK-UCL1 Publication
Biological Process positive regulation of DNA biosynthetic processSource:Ensembl
Biological Process positive regulation of DNA-binding transcription factor activitySource:BHF-UCL1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascadeSource:BHF-UCL1 Publication
Biological Process positive regulation of extrinsic apoptotic signaling pathwaySource:GO_Central1 Publication
Biological Process positive regulation of fever generationSource:BHF-UCL
Biological Process positive regulation of fractalkine productionSource:ARUK-UCL
Biological Process positive regulation of gene expressionSource:UniProtKB2 Publications
Biological Process positive regulation of glial cell proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of hair follicle developmentSource:Ensembl
Biological Process positive regulation of hepatocyte proliferationSource:Ensembl
Biological Process positive regulation of heterotypic cell-cell adhesionSource:BHF-UCL2 Publications
Biological Process positive regulation of humoral immune response mediated by circulating immunoglobulinSource:Ensembl
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingSource:BHF-UCL2 Publications
Biological Process positive regulation of I-kappaB phosphorylationSource:ARUK-UCL1 Publication
Biological Process positive regulation of inflammatory responseSource:ARUK-UCL1 Publication
Biological Process positive regulation of interferon-gamma productionSource:Ensembl
Biological Process positive regulation of interleukin-1 beta productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of interleukin-18 productionSource:Ensembl
Biological Process positive regulation of interleukin-33 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of interleukin-6 productionSource:ARUK-UCL1 Publication
Biological Process positive regulation of interleukin-8 productionSource:BHF-UCL3 Publications
Biological Process positive regulation of JNK cascadeSource:Ensembl
Biological Process positive regulation of JUN kinase activitySource:UniProtKB1 Publication
Biological Process positive regulation of leukocyte adhesion to arterial endothelial cellSource:BHF-UCL1 Publication
Biological Process positive regulation of leukocyte adhesion to vascular endothelial cellSource:BHF-UCL1 Publication
Biological Process positive regulation of MAP kinase activitySource:UniProtKB1 Publication
Biological Process positive regulation of MAPK cascadeSource:BHF-UCL1 Publication
Biological Process positive regulation of membrane protein ectodomain proteolysisSource:BHF-UCL1 Publication
Biological Process positive regulation of miRNA transcriptionSource:BHF-UCL1 Publication
Biological Process positive regulation of mitotic nuclear divisionSource:Ensembl
Biological Process positive regulation of mononuclear cell migrationSource:BHF-UCL1 Publication
Biological Process positive regulation of neuroinflammatory responseSource:ARUK-UCL2 Publications
Biological Process positive regulation of neuron apoptotic processSource:ARUK-UCL
Biological Process positive regulation of neutrophil activationSource:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activitySource:UniProtKB3 Publications
Biological Process positive regulation of NIK/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process positive regulation of nitric oxide biosynthetic processSource:BHF-UCL1 Publication
Biological Process positive regulation of nitric-oxide synthase activitySource:ARUK-UCL1 Publication
Biological Process positive regulation of nitrogen compound metabolic processSource:ARUK-UCL
Biological Process positive regulation of osteoclast differentiationSource:BHF-UCL1 Publication
Biological Process positive regulation of oxidative stress-induced neuron deathSource:Ensembl
Biological Process positive regulation of peptidyl-serine phosphorylationSource:BHF-UCL2 Publications
Biological Process positive regulation of phagocytosisSource:AgBase1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingSource:ARUK-UCL
Biological Process positive regulation of podosome assemblySource:BHF-UCL1 Publication
Biological Process positive regulation of programmed cell deathSource:UniProtKB1 Publication
Biological Process positive regulation of protein catabolic processSource:AgBase1 Publication
Biological Process positive regulation of protein kinase activitySource:AgBase1 Publication
Biological Process positive regulation of protein kinase B signalingSource:ARUK-UCL
Biological Process positive regulation of protein localization to cell surfaceSource:BHF-UCL1 Publication
Biological Process positive regulation of protein localization to plasma membraneSource:ARUK-UCL
Biological Process positive regulation of protein phosphorylationSource:UniProtKB2 Publications
Biological Process positive regulation of protein transportSource:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex assemblySource:BHF-UCL1 Publication
Biological Process positive regulation of protein-containing complex disassemblySource:UniProtKB1 Publication
Biological Process positive regulation of receptor signaling pathway via JAK-STATSource:ARUK-UCL
Biological Process positive regulation of smooth muscle cell proliferationSource:BHF-UCL1 Publication
Biological Process positive regulation of superoxide dismutase activitySource:BHF-UCL1 Publication
Biological Process positive regulation of synaptic transmissionSource:ARUK-UCL
Biological Process positive regulation of synoviocyte proliferationSource:ARUK-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:UniProtKB1 Publication
Biological Process positive regulation of translational initiation by ironSource:Ensembl
Biological Process positive regulation of tyrosine phosphorylation of STAT proteinSource:ARUK-UCL
Biological Process positive regulation of vascular associated smooth muscle cell proliferationSource:Ensembl
Biological Process positive regulation of vitamin D biosynthetic processSource:BHF-UCL1 Publication
Biological Process protein kinase B signalingSource:UniProtKB1 Publication
Biological Process protein localization to plasma membraneSource:UniProtKB1 Publication
Biological Process regulation of branching involved in salivary gland morphogenesisSource:Ensembl
Biological Process regulation of endothelial cell apoptotic processSource:ARUK-UCL1 Publication
Biological Process regulation of establishment of endothelial barrierSource:UniProtKB1 Publication
Biological Process regulation of fat cell differentiationSource:ARUK-UCL
Biological Process regulation of I-kappaB kinase/NF-kappaB signalingSource:BHF-UCL1 Publication
Biological Process regulation of immunoglobulin productionSource:Ensembl
Biological Process regulation of insulin secretionSource:BHF-UCL1 Publication
Biological Process regulation of reactive oxygen species metabolic processSource:Ensembl
Biological Process regulation of synapse organizationSource:ARUK-UCL
Biological Process regulation of synaptic transmission, glutamatergicSource:ARUK-UCL1 Publication
Biological Process regulation of transcription by RNA polymerase IISource:ARUK-UCL
Biological Process response to 3,3',5-triiodo-L-thyronineSource:Ensembl
Biological Process response to activitySource:Ensembl
Biological Process response to ethanolSource:Ensembl
Biological Process response to fructoseSource:Ensembl
Biological Process response to glucocorticoidSource:BHF-UCL1 Publication
Biological Process response to gold nanoparticleSource:Ensembl
Biological Process response to Gram-negative bacteriumSource:Ensembl
Biological Process response to hypoxiaSource:Ensembl
Biological Process response to macrophage colony-stimulating factorSource:Ensembl
Biological Process response to nutrient levelsSource:Ensembl
Biological Process response to paracetamolSource:Ensembl
Biological Process response to radiationSource:Ensembl
Biological Process response to salt stressSource:BHF-UCL1 Publication
Biological Process response to virusSource:BHF-UCL1 Publication
Biological Process response to xenobiotic stimulusSource:Ensembl
Biological Process sequestering of triglycerideSource:BHF-UCL1 Publication
Biological Process skeletal muscle contractionSource:Ensembl
Biological Process toll-like receptor 3 signaling pathwaySource:Ensembl
Biological Process tumor necrosis factor-mediated signaling pathwaySource:ARUK-UCL2 Publications
Biological Process vascular endothelial growth factor productionSource:UniProtKB1 Publication
Biological Process vasodilationSource:Ensembl
Cellular Location
Cell membrane
Tumor necrosis factor, membrane form
Membrane
Tumor necrosis factor, soluble form
Secreted
C-domain 1
Secreted
C-domain 2
Secreted
Involvement in disease
Psoriatic arthritis (PSORAS):
An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-233
PTM
The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
Tumor necrosis factor, soluble form
The soluble form is demyristoylated at Lys-19 and Lys-20 by SIRT6, promoting its secretion.

Anti-TNF antibodies

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Target: Tnf
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYJT-3633
Application*: WB, IC, P, E
Target: Tnf
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJT-3632
Application*: N, EC
Target: Tnf
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJT-3631
Application*: WB, N, EC
Target: Tnf
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYJT-3630
Application*: WB, N
Target: Tnf
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBYJT-3629
Application*: WB, N
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rabbit
Clone: CBYJT-3628
Application*: IC, P, E, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rabbit
Clone: CBYJT-3627
Application*: N
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Rabbit
Clone: CBYJT-3626
Application*: E, IC, IH, WB
Target: TNF
Host: Rabbit
Antibody Isotype: IgG1
Specificity: Pig, Rat
Clone: CBYJT-3625
Application*: B, E, IH, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig, Rat
Clone: CBYJT-3624
Application*: B, E, IC, IF, IH, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Pig
Clone: CBYJT-3623
Application*: E, IC, IH, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBYJT-3622
Application*: EC
Target: TNF
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Dog, Cat, Rabbit, Zebrafish
Clone: P/T2
Application*: F, E, IC, IF, IP, P, C, MC
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Guinea pig, Hamster, Zebrafish, Monkey
Clone: 52B83
Application*: WB, E, P, C, F, IC, IF
Target: TNF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Sheep
Clone: CC328
Application*: E, F
Target: TNF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Deer
Clone: CC327
Application*: E, F
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 4H31
Application*: FN, IP, E, WB, C, P
Target: Tnf
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3619
Application*: WB, IC, P, E
Target: Tnf
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: XT3.13
Application*: F
Target: Tnf
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: XT3.11
Application*: N
Target: Tnf
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3618
Application*: B, E, N, WB
Target: Tnf
Host: Rat
Antibody Isotype: IgD
Specificity: Mouse
Clone: CBYJT-3617
Application*: N, F, I
Target: Tnf
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: MP6-XT3
Application*: WB
Target: Tnf
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MP6-XT22
Application*: B, F, EC
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Monkey
Clone: CBYJT-3616
Application*: IC, P, E, WB
Target: TNF
Host: Rat
Antibody Isotype: IgG1
Specificity: Monkey
Clone: CBYJT-3615
Application*: N
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Monkey
Clone: CBYJT-3614
Application*: E, IC, IH, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Baboon, Monkey
Clone: MAb11
Application*: B, F
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: J2D10
Application*: F, IF, MC
Target: TNF
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Dog, Cat, Rabbit, Zebrafish
Clone: TNF706
Application*: F, E, IC, IF, IP, P, C, MC
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Dog, Cat, Rabbit, Zebrafish
Clone: SPM543
Application*: F, E, IC, IF, IP, P, C, MC
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Dog
Clone: CBYJT-3606
Application*: IC, P, E, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBYJT-3605
Application*: N, IC, EC
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Sheep
Clone: CBYJT-3604
Application*: IH, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0081
Application*: F, FN, IA, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Guinea pig, Mouse, Monkey
Clone: CBFYA-0075
Application*: F, C, IA, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TNF656
Application*: E, FN
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TNF655
Application*: E, FN
Target: TNF
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: MP9-20A4
Application*: F, E, IH, C
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: J1D9
Application*: F, IF, MC
Target: TNF
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: GMO1-17A2
Application*: F, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: F6C5
Application*: IH, P, C, IO
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYA-0074
Application*: F, C, FN, IA, IP, WB
Target: TNF
Host: Rat
Specificity: Mouse
Clone: CBFYA-0009
Application*: F, FN
Target: TNF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CDP 571
Application*: E
Target: TNF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: cA2
Application*: F, E, MC
Target: TNF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Horse
Clone: CBYJT-3613
Application*: WB, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse
Clone: CBYJT-3612
Application*: WB, E
Target: Tnf
Host: Mouse
Antibody Isotype: IgG1
Specificity: Guinea pig
Clone: CBYJT-3611
Application*: EC
Target: Tnf
Host: Mouse
Antibody Isotype: IgG1
Specificity: Guinea pig
Clone: CBYJT-3610
Application*: E
Target: Tnf
Host: Mouse
Antibody Isotype: IgG1
Specificity: Guinea pig
Clone: CBYJT-3609
Application*: E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C8
Application*: E, IH
Target: TNF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: 2E1A5
Application*: E
Target: TNF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Dog, Monkey
Clone: CBFYA-0175
Application*: FN, IA
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBHb119
Application*: FC, IHC-F, FuncS, Immuno assays, IP, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Guinea pig, Mouse, Monkey
Clone: CBHb120
Application*: FC, IHC-F, Immuno assays, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb129
Application*: FC, FuncS, Immuno assays, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb130
Application*: FC, Immuno assays, IP, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Cattle, Dog, Monkey
Clone: CBHb266
Application*: FuncS, Immuno assays
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB369
Application*: WB, IHC
Target: TNF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H10C3C5
Application*: E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: KT61
Application*: ELISA
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0132
Application*: E
Target: TNF
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: KT31
Application*: ELISA
Target: TNF
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle
Clone: CB311A
Application*: ELISA
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0131
Application*: E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0130
Application*: WB, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0129
Application*: WB, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0126
Application*: E, N, IH
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0128
Application*: WB, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 1C3-A1-F4
Application*: WB, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: M1-C4
Application*: WB, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M2-E3
Application*: WB, E
Target: TNF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1G2
Application*: WB, IP, IF (IC), F
Target: TNF
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5G9
Application*: WB, IP
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10D9
Application*: ELISA
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A9B9
Application*: ELISA, WB
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F11
Application*: ELISA
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1F6
Application*: ELISA, WB, IHC, IP
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB485A
Application*: ELISA, WB, IHC
Target: TNF
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB486A
Application*: ELISA, WB, IHC
Target: TNF
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0125
Application*: E, N, IH
Target: TNF
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYR0127
Application*: WB, E
Target: TNF
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D4
Application*: WB, IC, P, C, E, IP, IF, F
Target: TNF
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBYJT-3621
Application*: WB, N, IC
Target: TNF
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: TN3-19.12
Application*: FN, N
Target: TNF
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse, Chicken
Clone: CBYJT-3620
Application*: E, F, IC, IH, N, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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