TOMM22

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq]

translocase of outer mitochondrial membrane 22 homolog (yeast)

Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837).
Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity).

Biological Process positive regulation of apoptotic process Source:Ensembl
Biological Process protein insertion into mitochondrial outer membrane Source:BHF-UCL1 Publication
Biological Process protein targeting to mitochondrion Source:HGNC-UCL1 Publication

Mitochondrion outer membrane

Cytoplasmic: 2-83
Helical: 84-103
Mitochondrial intermembrane: 104-142