TSPY1

TSPY1 is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of TSPY1 are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse.

Full Name

testis specific protein, Y-linked 1

Function

May be involved in sperm differentiation and proliferation.

Biological Process

Biological Process cell differentiation Source:UniProtKB-KW
Biological Process gonadal mesoderm development Source:UniProtKB-KW
Biological Process nucleosome assembly Source:InterPro
Biological Process sex differentiation Source:ProtInc1 Publication
Biological Process spermatogenesis Source:UniProtKB-KW

Cellular Location

Cytoplasm
Nucleus
Predominantly cytoplasmic. Also found in nucleus.

Involvement in disease

TSPY is located in the gonadoblastoma critical region and is preferentially expressed in tumor germ cells of gonadoblastoma specimens. Expression also correlates with testicular seminoma and tumorigenesis of the prostate gland.

PTM

Phosphorylated.