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UBE2G1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq]

Full Name

ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

Biological Process

Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication

Cellular Location

cytosol
extracellular exosome

PTM

Autoubiquitinated in vitro.

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Anti-UBE2G1 antibodies

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Mouse Anti-UBE2G1 Recombinant Antibody (2A9-1F11) (CBMAB-A9713-LY)

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Target: UBE2G1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2A9-1F11

Application*: WB, E

Human Recombinant UBE2G1, Active protein, His Tag (V2LY-0526-LY7497)

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Target: UBE2G1

Expressed Host: E. coli

Sequence: Amino Acid: Full Length

Tag: His Tag

Human Recombinant UBE2G1 protein (V2LY-0526-LY7496)

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Target: UBE2G1

Expressed Host: E. coli

Sequence: Amino Acid: 1-170

Mouse Anti-UBE2G1 Recombinant Antibody (CBFYU-104) (CBMAB-U0104-FY)

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Target: UBE2G1

Host: Mouse

Specificity: Human

Clone: CBFYU-104

Application*: WB, IP, IF, E

Mouse Anti-UBE2G1 Recombinant Antibody (1C12-1B2) (CBMAB-U0103-FY)

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Target: UBE2G1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C12-1B2

Application*: E, IF, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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