WASL

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]

Wiskott-Aldrich Syndrome Like

Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828).
Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828).
Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512).
In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080).
Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity).
Plays a role in dendrite spine morphogenesis (By similarity).
Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742).

Biological Process actin filament polymerization Source:UniProtKB1 Publication
Biological Process actin filament-based movement Source:GO_Central1 Publication
Biological Process actin polymerization or depolymerization Source:ProtInc1 Publication
Biological Process cell division Source:UniProtKB-KW
Biological Process dendritic spine morphogenesis Source:UniProtKB
Biological Process negative regulation of lymphocyte migration Source:CACAO1 Publication
Biological Process negative regulation of membrane tubulation Source:UniProtKB1 Publication
Biological Process positive regulation of Arp2/3 complex-mediated actin nucleation Source:InterPro
Biological Process positive regulation of clathrin-dependent endocytosis Source:BHF-UCL
Biological Process positive regulation of filopodium assembly Source:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase II Source:UniProtKB1 Publication
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process protein-containing complex localization Source:Ensembl
Biological Process regulation of postsynapse organization Source:Ensembl
Biological Process regulation of protein localization Source:Ensembl
Biological Process response to bacterium Source:Ensembl
Biological Process spindle localization Source:Ensembl
Biological Process vesicle budding from membrane Source:BHF-UCL
Biological Process vesicle organization Source:BHF-UCL
Biological Process vesicle transport along actin filament Source:BHF-UCL

Cytoplasm, cytoskeleton
Nucleus
Cytoplasm
Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity).
Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity).

Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity.