XCL1

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1.

chemokine (C motif) ligand 1

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

Biological Process antimicrobial humoral immune response mediated by antimicrobial peptide Source:UniProtKB
Biological Process cell-cell signaling Source:BHF-UCL1 Publication
Biological Process cellular response to interleukin-1 Source:GO_Central1 Publication
Biological Process cellular response to interleukin-4 Source:BHF-UCL
Biological Process cellular response to transforming growth factor beta stimulus Source:BHF-UCL
Biological Process cellular response to tumor necrosis factor Source:GO_Central1 Publication
Biological Process cellular response to type II interferon Source:GO_Central1 Publication
Biological Process chemokine-mediated signaling pathway Source:GO_Central1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process killing of cells of another organism Source:UniProtKB
Biological Process lymphocyte chemotaxis Source:GO_Central1 Publication
Biological Process mature natural killer cell chemotaxis Source:BHF-UCL1 Publication
Biological Process monocyte chemotaxis Source:GO_Central1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL1 Publication
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process negative regulation of interleukin-2 production Source:BHF-UCL1 Publication
Biological Process negative regulation of T cell cytokine production Source:BHF-UCL1 Publication
Biological Process negative regulation of T-helper 1 cell activation Source:BHF-UCL1 Publication
Biological Process negative regulation of T-helper 1 type immune response Source:BHF-UCL1 Publication
Biological Process negative regulation of type II interferon production Source:BHF-UCL1 Publication
Biological Process neutrophil chemotaxis Source:GO_Central1 Publication
Biological Process positive regulation of B cell chemotaxis Source:BHF-UCL
Biological Process positive regulation of CD4-positive, alpha-beta T cell proliferation Source:BHF-UCL
Biological Process positive regulation of CD8-positive, alpha-beta T cell proliferation Source:BHF-UCL1 Publication
Biological Process positive regulation of ERK1 and ERK2 cascade Source:GO_Central1 Publication
Biological Process positive regulation of granzyme A production Source:BHF-UCL1 Publication
Biological Process positive regulation of granzyme B production Source:BHF-UCL1 Publication
Biological Process positive regulation of GTPase activity Source:GO_Central1 Publication
Biological Process positive regulation of immunoglobulin production in mucosal tissue Source:BHF-UCL
Biological Process positive regulation of interleukin-10 production Source:BHF-UCL1 Publication
Biological Process positive regulation of leukocyte chemotaxis Source:BHF-UCL
Biological Process positive regulation of natural killer cell chemotaxis Source:BHF-UCL1 Publication
Biological Process positive regulation of neutrophil chemotaxis Source:BHF-UCL
Biological Process positive regulation of release of sequestered calcium ion into cytosol Source:BHF-UCL1 Publication
Biological Process positive regulation of T cell chemotaxis Source:BHF-UCL1 Publication
Biological Process positive regulation of T cell cytokine production Source:BHF-UCL
Biological Process positive regulation of T cell mediated cytotoxicity Source:BHF-UCL1 Publication
Biological Process positive regulation of T-helper 1 cell cytokine production Source:BHF-UCL
Biological Process positive regulation of T-helper 2 cell cytokine production Source:BHF-UCL
Biological Process positive regulation of thymocyte migration Source:BHF-UCL
Biological Process positive regulation of transforming growth factor beta production Source:BHF-UCL1 Publication
Biological Process regulation of inflammatory response Source:BHF-UCL1 Publication
Biological Process release of sequestered calcium ion into cytosol Source:BHF-UCL
Biological Process response to virus Source:BHF-UCL1 Publication
Biological Process signal transduction Source:BHF-UCL1 Publication

Secreted