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Mouse Anti-ACSS2 Recombinant Antibody (2C6) (CBMAB-0014CQ)

This product is a mouse antibody that recognizes ACSS2. The antibody 2C6 can be used for immunoassay techniques such as: IHC-P, WB.
Host Species
Mouse
Application
IHC-P, WB
Immunogen
Full length human recombinant protein of human ACSS2
Antibody Isotype
IgG2b
Specificity
Human
Clone
2C6
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. demonstrated that the metabolic enzyme ACSS2 directly regulates histone acetylation in neurons and spatial memory in mammals. In a neuronal cell culture model, ACSS2 increased in the nuclei of differentiating neurons and localized to upregulated neuronal genes near sites of elevated histone acetylation. A decrease in ACSS2 lowered nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the cohort of neuronal genes. In adult mice, attenuation of hippocampal ACSS2 expression impaired long-term spatial memory, a cognitive process that relies on histone acetylation.
Alternative Name
Acyl-CoA Synthetase Short-Chain Family Member 2; Acetyl-Coenzyme A Synthetase 2 (ADP Forming); Acyl-Activating Enzyme; EC 6.2.1.1; ACECS; ACAS2; ACS; Cytoplasmic Acetyl-Coenzyme A Synthetase; Acetyl-CoA Synthetase; Acetate--CoA Ligase; Acetate Thiokinase; Acetate-CoA Ligase; DJ1161H23.1; EC 6.2.1; ACSA
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0014CQ
Conjugates
Size
Price $
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Second antibody and isotype control