Full length human recombinant protein of human ACSS2
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. demonstrated that the metabolic enzyme ACSS2 directly regulates histone acetylation in neurons and spatial memory in mammals. In a neuronal cell culture model, ACSS2 increased in the nuclei of differentiating neurons and localized to upregulated neuronal genes near sites of elevated histone acetylation. A decrease in ACSS2 lowered nuclear acetyl-CoA levels, histone acetylation, and responsive expression of the cohort of neuronal genes. In adult mice, attenuation of hippocampal ACSS2 expression impaired long-term spatial memory, a cognitive process that relies on histone acetylation.
Acyl-CoA Synthetase Short-Chain Family Member 2; Acetyl-Coenzyme A Synthetase 2 (ADP Forming); Acyl-Activating Enzyme; EC 184.108.40.206; ACECS; ACAS2; ACS; Cytoplasmic Acetyl-Coenzyme A Synthetase; Acetyl-CoA Synthetase; Acetate--CoA Ligase; Acetate Thiokinase; Acetate-CoA Ligase; DJ1161H23.1; EC 6.2.1; ACSA