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Rabbit Anti-ALDH1A1 Recombinant Antibody (D9J7R) (CBMAB-A2250-YC)

Provided herein is a Rabbit monoclonal antibody against Human Aldehyde Dehydrogenase 1 Family Member A1. The antibody can be used for immunoassay techniques, such as FC, ICC, IF, IP, WB.
See all ALDH1A1 antibodies
Published Data
Rabbit Anti-ALDH1A1 Recombinant Antibody (D9J7R) in FC
ACS detection of ALDH1 and CD133 in ECSCisk and ECSCecc. ...View More
Chen, G., Liu, B., Yin, S., Li, S., Guo, Y. E., Wang, M., ... & Wan, X. (2020). Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA. Oncogenesis, 9(9), 81.
Rabbit Anti-ALDH1A1 Recombinant Antibody (D9J7R) in Immunoblot
Immunoblotting findings of ALDH1 and SOX2 in ECSCisk on days 1, 2, 4, 5 and 8. ...View More
Chen, G., Liu, B., Yin, S., Li, S., Guo, Y. E., Wang, M., ... & Wan, X. (2020). Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA. Oncogenesis, 9(9), 81.
Rabbit Anti-ALDH1A1 Recombinant Antibody (D9J7R) in IF
Representative images of immunofluorescence staining of U87 and U87-sph. The U87-sph cells showed an increased co-expression of the GSLC markers CD133 (red), CD44 (green), ALDH1A1 (red), Nestin (green) and SOX2 (red) compared to the U87 cells. Nuclei were stained with DAPI (blue). Scale bar: 100 µm. ...View More
Essien, E. I., Hofer, T. P., Atkinson, M. J., & Anastasov, N. (2022). Combining HDAC and MEK Inhibitors with radiation against glioblastoma-derived spheres. Cells, 11(5), 775.
Rabbit Anti-ALDH1A1 Recombinant Antibody (D9J7R) in IHC
Representative IHC images of ALDH1A1 and its associations with TB grade. ...View More
Xiang, Z., He, Q., Huang, L., Xiong, B., & Xiang, Q. (2022). Breast Cancer Classification Based on Tumor Budding and Stem Cell-Related Signatures Facilitate Prognosis Evaluation. Frontiers in Oncology, 11, 818869.

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D9J7R
Antibody Isotype
IgG
Application
FC, ICC, IF, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues near the carboxy terminus of human ALDH1A1 protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IF(ICC)1:400
FC1:200
IP1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 150 mM NaCl, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aldehyde Dehydrogenase 1 Family Member A1
Introduction
ALDH1A1 belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitocho
Entrez Gene ID
216
UniProt ID
P00352
Alternative Names
Aldehyde Dehydrogenase 1 Family Member A1; Retinaldehyde Dehydrogenase 1; EC 1.2.1.36; RALDH 1; ALDH-E1; RALDH1; ALHDII; ALDH1; PUMB1; ALDC; Epididymis Secretory Sperm Binding Protein Li 53e; Aldehyde Dehydrogenase 1 Family, Member A1; Aldehyde Dehydrogen
Function
Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233).
Biological Process
Cellular aldehyde metabolic process Source: ProtInc
Ethanol oxidation Source: Reactome
Fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate Source: Reactome
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Retinoid metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB-UniPathway
Cellular Location
Cytosol
PTM
The N-terminus is blocked most probably by acetylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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