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Mouse Anti-ALDH1L1 Recombinant Antibody (4A12) (CBMAB-A2265-YC)

Provided herein is a Mouse monoclonal antibody against Human Aldehyde Dehydrogenase 1 Family Member L1. The antibody can be used for immunoassay techniques, such as WB, ICC, IF.
See all ALDH1L1 antibodies
Published Data
Mouse Anti-ALDH1L1 Recombinant Antibody (4A12) in IF
Dual immunofluorescent image showing that most cells expressed astrocyte markers (GFAP and aldh1L1); fewer expressed Iba1 (microglia), NeuN, and MAP2 (neurons) (scale bar: 50 μm) ...View More
Yoon, S. R., Hong, N., Lee, M. Y., & Ahn, J. C. (2021). Photobiomodulation with a 660-nanometer light-emitting diode promotes cell proliferation in astrocyte culture. Cells, 10(7), 1664.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
4A12
Antibody Isotype
IgG2b
Application
WB, IHC, IF

Basic Information

Immunogen
Amino acids 1-401 of human ALDH1L1.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC1:1,000-1:2,000
WB1:5,000-1:10,000
IF(ICC)1:1,000-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% PBS, 50% glycerol
Preservative
5mM sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Introduction
ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of functio
Entrez Gene ID
Human10840
Mouse107747
Rat64392
Pig100622210
Cattle505677
Horse100061108
UniProt ID
HumanO75891
MouseQ8R0Y6
RatP28037
PigI3LEN7
CattleA7YY67
HorseH9H007
Alternative Names
Aldehyde Dehydrogenase 1 Family Member L1; Cytosolic 10-Formyltetrahydrofolate Dehydrogenase; 10-FTHFDH; FTHFD; FDH; Aldehyde Dehydrogenase 1 Family, Member L1; Aldehyde Dehydrogenase Family 1 Member L1;
Biological Process
10-formyltetrahydrofolate catabolic process Source: ProtInc
Biosynthetic process Source: InterPro
Folic acid metabolic process Source: Reactome
One-carbon metabolic process Source: UniProtKB-KW
Cellular Location
Cytoplasm

Melzer, L., Freiman, T. M., & Derouiche, A. (2021). Rab6A as a pan-astrocytic marker in mouse and human brain, and comparison with other glial markers (GFAP, GS, Aldh1L1, SOX9). Cells, 10(1), 72.

Sharma, J., Krupenko, N. I., Pediaditakis, P., Helke, K., Strickland, K. C., & Krupenko, S. A. (2021). Effect ofALDH1L1folate enzyme on hepatocellular carcinoma inachemical carcinogenesismodel.

Michalovicz, L. T., Kelly, K. A., Vashishtha, S., Ben‐Hamo, R., Efroni, S., Miller, J. V., ... & O’Callaghan, J. P. (2019). Astrocyte‐specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity. Journal of neurochemistry, 150(4), 420-440.

Krupenko, S. A., & Krupenko, N. I. (2019). Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression. Chemico-biological interactions, 302, 149-155.

Sukhorukova, E. G., Sufieva, D. A., & Korzhevskii, D. E. (2018). ALDEHYDE DEHYDROGENASE 1L1 IN RAT BRAIN CELLS. Medical academic journal, 18(1), 84-88.

Beniaminov, A. D., Puzanov, G. A., Krasnov, G. S., Kaluzhny, D. N., Kazubskaya, T. P., Braga, E. A., ... & Dmitriev, A. A. (2018). Deep sequencing revealed a cpg methylation pattern associated with aldh1l1 suppression in breast cancer. Frontiers in genetics, 9, 169.

Zhu, G., Liao, X., Han, C., Liu, X., Yu, L., Qin, W., ... & Peng, T. (2017). ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma. Oncology reports, 38(3), 1451-1463.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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