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Rabbit Anti-ALDH1L1 Recombinant Antibody (19H14L20) (CBMAB-0055CQ)

This product is a rabbit antibody that recognizes ALDH1L1. The antibody 19H14L20 can be used for immunoassay techniques such as: WB, IF, ICC, FC.
See all ALDH1L1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
19H14L20
Antibody Isotype
IgG
Application
WB, IF, ICC

Basic Information

Immunogen
Human ALDH1L1 aa 1-307
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1-2 µg/ml
IF(ICC)1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Introduction
ALDH1L1 encodes 10-formyltetrahydrofolate dehydrogenase (FTHFD; EC 1.5.1.6), a cytosolic enzyme that catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-formyltetrahydrofolate to tetrahydrofolate and formic acid. The enzyme also oxidizes some aldehydes Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human10840
Mouse107747
Rat64392
UniProt ID
HumanO75891
MouseQ8R0Y6
RatP28037
Alternative Names
Aldehyde Dehydrogenase 1 Family, Member L1; 10-FTHFDH; FTHFD; FDH; Cytosolic 10-Formyltetrahydrofolate Dehydrogenase; Aldehyde Dehydrogenase Family 1 Member L1; 10-Formyltetrahydrofolate Dehydrogenase; Formyltetrahydrofolate Dehydrogenase; MER57B-ALDH1L1; EC 1.5.1.6; 10-FTHF
Biological Process
10-formyltetrahydrofolate catabolic process Source: ProtInc
Biosynthetic process Source: InterPro
Folic acid metabolic process Source: Reactome
One-carbon metabolic process Source: UniProtKB-KW
Cellular Location
Cytoplasm

Melzer, L., Freiman, T. M., & Derouiche, A. (2021). Rab6A as a pan-astrocytic marker in mouse and human brain, and comparison with other glial markers (GFAP, GS, Aldh1L1, SOX9). Cells, 10(1), 72.

Sharma, J., Krupenko, N. I., Pediaditakis, P., Helke, K., Strickland, K. C., & Krupenko, S. A. (2021). Effect ofALDH1L1folate enzyme on hepatocellular carcinoma inachemical carcinogenesismodel.

Michalovicz, L. T., Kelly, K. A., Vashishtha, S., Ben‐Hamo, R., Efroni, S., Miller, J. V., ... & O’Callaghan, J. P. (2019). Astrocyte‐specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity. Journal of neurochemistry, 150(4), 420-440.

Krupenko, S. A., & Krupenko, N. I. (2019). Loss of ALDH1L1 folate enzyme confers a selective metabolic advantage for tumor progression. Chemico-biological interactions, 302, 149-155.

Sukhorukova, E. G., Sufieva, D. A., & Korzhevskii, D. E. (2018). ALDEHYDE DEHYDROGENASE 1L1 IN RAT BRAIN CELLS. Medical academic journal, 18(1), 84-88.

Beniaminov, A. D., Puzanov, G. A., Krasnov, G. S., Kaluzhny, D. N., Kazubskaya, T. P., Braga, E. A., ... & Dmitriev, A. A. (2018). Deep sequencing revealed a cpg methylation pattern associated with aldh1l1 suppression in breast cancer. Frontiers in genetics, 9, 169.

Zhu, G., Liao, X., Han, C., Liu, X., Yu, L., Qin, W., ... & Peng, T. (2017). ALDH1L1 variant rs2276724 and mRNA expression predict post-operative clinical outcomes and are associated with TP53 expression in HBV-related hepatocellular carcinoma. Oncology reports, 38(3), 1451-1463.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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