Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-ALDH2 Recombinant Antibody (1007902) (CBMAB-A2274-YC)


See all ALDH2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
1007902
Antibody Isotype
IgG1
Application
ICC, IF, IHC, WB

Basic Information

Immunogen
Synthetic peptide containing human ALDH2 Ser18-Ser517.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB2 µg/ml
IF(ICC)8-25 µg/ml
IHC0.5-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aldehyde Dehydrogenase 2 Family (Mitochondrial)
Introduction
ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be disti
Entrez Gene ID
217
UniProt ID
P05091
Alternative Names
Aldehyde Dehydrogenase 2 Family (Mitochondrial); ALDH Class 2; EC 1.2.1.3; ALDH-E2; ALDHI; ALDM;
Biological Process
Alcohol metabolic process Source: ProtInc
Carbohydrate metabolic process Source: ProtInc
Ethanol catabolic process Source: UniProtKB-UniPathway
Ethanol oxidation Source: Reactome
Cellular Location
Mitochondrion matrix
More Infomation

Zhu, Z. Y., Liu, Y. D., Gong, Y., Jin, W., Topchiy, E., Turdi, S., ... & Qin, X. (2021). Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis. Acta Pharmacologica Sinica, 1-11.

Chen, L., Wu, Y. T., Gu, X. Y., Xie, L. P., Fan, H. J., Tan, Z. B., ... & Sun, X. M. (2021). Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts. Bioorganic & Medicinal Chemistry Letters, 43, 128045.

Suo, C., Yang, Y., Yuan, Z., Zhang, T., Yang, X., Qing, T., ... & Ye, W. (2019). Alcohol intake interacts with functional genetic polymorphisms of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) to increase esophageal squamous cell cancer risk. Journal of Thoracic Oncology, 14(4), 712-725.

Zhao, Y., Wang, B., Zhang, J., He, D., Zhang, Q., Pan, C., ... & Chen, Y. (2019). ALDH2 (Aldehyde Dehydrogenase 2) protects against hypoxia-induced pulmonary hypertension. Arteriosclerosis, thrombosis, and vascular biology, 39(11), 2303-2319.

Kimura, M., Yokoyama, A., & Higuchi, S. (2019). Aldehyde dehydrogenase-2 as a therapeutic target. Expert opinion on therapeutic targets, 23(11), 955-966.

Wang, Y., & He, W. (2018). Endogenous Mitochondrial Aldehyde Dehydrogenase-2 as an Antioxidant in Liver. In The Liver (pp. 247-259). Academic Press.

Miura, T., Nishinaka, T., Terada, T., & Yonezawa, K. (2017). Vasodilatory effect of nitroglycerin in Japanese subjects with different aldehyde dehydrogenase 2 (ALDH2) genotypes. Chemico-biological interactions, 276, 40-45.

Buchman, C. D., & Hurley, T. D. (2017). Inhibition of the aldehyde dehydrogenase 1/2 family by psoralen and coumarin derivatives. Journal of medicinal chemistry, 60(6), 2439-2455.

Nene, A., Chen, C. H., Disatnik, M. H., Cruz, L., & Mochly-Rosen, D. (2017). Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites. Journal of biomedical science, 24(1), 1-12.

Angenendt, L., Bormann, E., Mikesch, J. H., Herold, T., Metzeler, K. H., Bohlander, S. K., ... & Schliemann, C. (2017). Aldehyde Dehydrogenase 2 (ALDH2) Expression Predicts a Poor Prognosis in Acute Myeloid Leukemia. Blood, 130, 1386.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ALDH2 Recombinant Antibody (1007902)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry