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Rabbit Anti-ALDH2 Recombinant Antibody (1J9I8) (CBMAB-A2276-YC)

Provided herein is a Mouse monoclonal antibody against Human Aldehyde Dehydrogenase 2 Family (Mitochondrial). The antibody can be used for immunoassay techniques, such as ELISA, FC, ICC, IF, IHC, IHC-P, WB.
See all ALDH2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
1J9I8
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ALDH2.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Aldehyde Dehydrogenase 2 Family (Mitochondrial)
Introduction
ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be disti
Entrez Gene ID
Human217
Mouse11669
Rat29539
UniProt ID
HumanP05091
MouseP47738
RatP11884
Alternative Names
Aldehyde Dehydrogenase 2 Family (Mitochondrial); ALDH Class 2; EC 1.2.1.3; ALDH-E2; ALDHI; ALDM;
Biological Process
Alcohol metabolic process Source: ProtInc
Carbohydrate metabolic process Source: ProtInc
Ethanol catabolic process Source: UniProtKB-UniPathway
Ethanol oxidation Source: Reactome
Cellular Location
Mitochondrion matrix

Zhu, Z. Y., Liu, Y. D., Gong, Y., Jin, W., Topchiy, E., Turdi, S., ... & Qin, X. (2021). Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer’s disease via inhibition of ACSL4-dependent ferroptosis. Acta Pharmacologica Sinica, 1-11.

Chen, L., Wu, Y. T., Gu, X. Y., Xie, L. P., Fan, H. J., Tan, Z. B., ... & Sun, X. M. (2021). Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts. Bioorganic & Medicinal Chemistry Letters, 43, 128045.

Suo, C., Yang, Y., Yuan, Z., Zhang, T., Yang, X., Qing, T., ... & Ye, W. (2019). Alcohol intake interacts with functional genetic polymorphisms of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) to increase esophageal squamous cell cancer risk. Journal of Thoracic Oncology, 14(4), 712-725.

Zhao, Y., Wang, B., Zhang, J., He, D., Zhang, Q., Pan, C., ... & Chen, Y. (2019). ALDH2 (Aldehyde Dehydrogenase 2) protects against hypoxia-induced pulmonary hypertension. Arteriosclerosis, thrombosis, and vascular biology, 39(11), 2303-2319.

Kimura, M., Yokoyama, A., & Higuchi, S. (2019). Aldehyde dehydrogenase-2 as a therapeutic target. Expert opinion on therapeutic targets, 23(11), 955-966.

Wang, Y., & He, W. (2018). Endogenous Mitochondrial Aldehyde Dehydrogenase-2 as an Antioxidant in Liver. In The Liver (pp. 247-259). Academic Press.

Miura, T., Nishinaka, T., Terada, T., & Yonezawa, K. (2017). Vasodilatory effect of nitroglycerin in Japanese subjects with different aldehyde dehydrogenase 2 (ALDH2) genotypes. Chemico-biological interactions, 276, 40-45.

Buchman, C. D., & Hurley, T. D. (2017). Inhibition of the aldehyde dehydrogenase 1/2 family by psoralen and coumarin derivatives. Journal of medicinal chemistry, 60(6), 2439-2455.

Nene, A., Chen, C. H., Disatnik, M. H., Cruz, L., & Mochly-Rosen, D. (2017). Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites. Journal of biomedical science, 24(1), 1-12.

Angenendt, L., Bormann, E., Mikesch, J. H., Herold, T., Metzeler, K. H., Bohlander, S. K., ... & Schliemann, C. (2017). Aldehyde Dehydrogenase 2 (ALDH2) Expression Predicts a Poor Prognosis in Acute Myeloid Leukemia. Blood, 130, 1386.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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