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Mouse Anti-AMPH Recombinant Antibody (694145) (CBMAB-1079-CN)

This product is a mouse antibody that recognizes AMPH of human. The antibody 694145 can be used for immunoassay techniques such as: IHC.
See all AMPH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
694145
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
E. coli-derived recombinant human Amphiphysin/AMPH Asn204-Gly300.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amphiphysin
Introduction
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff-man syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined. A pseudogene of this gene is found on chromosome 11. The protein may participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. The protein may control the properties of the membrane associated cytoskeleton.
Entrez Gene ID
273
UniProt ID
P49418
Alternative Names
AMPH1
Function
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
Biological Process
Chemical synaptic transmission Source: ProtInc
Endocytosis Source: ProtInc
Membrane organization Source: Reactome
Synaptic vesicle endocytosis Source: GO_Central
Cellular Location
Cytoskeleton; Synaptic vesicle membrane

Kapoor, T., Dubey, P., Shirolikar, S., & Ray, K. (2021). An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads. Cell Reports, 34(13), 108918.

Zhang, X., Zou, L., Meng, L., Xiong, M., Pan, L., Chen, G., ... & Zhang, Z. (2021). Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. Elife, 10, e65301.

Kapoor, T., Dubey, P., Shirolikar, S., & Ray, K. (2020). Nanoscale indentation of plasma membrane establishes a contractile actomyosin scaffold through selective activation of the Amphiphysin-Rho1-Dia/DAAM and Rok pathway. DAAM and Rok Pathway.

Zhang, H., Liu, Y., Xu, K., Mao, K., Han, W., Xu, F., ... & Sun, Y. (2019). AMPH-1 as a critical tumor suppressor that inhibits osteosarcoma progression. Cancer management and research, 11, 9913.

Lionello, V. M., Nicot, A. S., Sartori, M., Kretz, C., Kessler, P., Buono, S., ... & Cowling, B. S. (2019). Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice. Science translational medicine, 11(484).

Yang, H., Wan, Z., Huang, C., Yin, H., & Song, D. (2019). AMPH-1 is a tumor suppressor of lung cancer by inhibiting Ras-Raf-MEK-ERK signal pathway. Lasers in medical science, 34(3), 473-478.

Jiang, L., Ge, W., & Geng, J. (2019). miR-425 regulates cell proliferation, migration and apoptosis by targeting AMPH-1 in non-small-cell lung cancer. Pathology-Research and Practice, 215(12), 152705.

Chen, Y., Liu, J., Li, L., Xia, H., Lin, Z., & Zhong, T. (2018). AMPH-1 is critical for breast cancer progression. Journal of Cancer, 9(12), 2175.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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