Human Recombinant AMPH protein, GST Tag (V2LY-0526-LY2077)

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Basic Information

Expressed Host
E. coli
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant AMPH protein, GST Tag consist of Amino Acid: 1-695 (FL) and predicts a molecular mass of 115 kDa.
Molecule Mass
115 kDa
Sequence
Amino Acid: 1-695 (FL)
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
Amphiphysin
Function
May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
Biological Process
Chemical synaptic transmission Source: ProtInc
Endocytosis Source: ProtInc
Membrane organization Source: Reactome
Synaptic vesicle endocytosis Source: GO_Central
Cellular Location
Cytoskeleton; Synaptic vesicle membrane

Kapoor, T., Dubey, P., Shirolikar, S., & Ray, K. (2021). An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads. Cell Reports, 34(13), 108918.

Zhang, X., Zou, L., Meng, L., Xiong, M., Pan, L., Chen, G., ... & Zhang, Z. (2021). Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction. Elife, 10, e65301.

Kapoor, T., Dubey, P., Shirolikar, S., & Ray, K. (2020). Nanoscale indentation of plasma membrane establishes a contractile actomyosin scaffold through selective activation of the Amphiphysin-Rho1-Dia/DAAM and Rok pathway. DAAM and Rok Pathway.

Zhang, H., Liu, Y., Xu, K., Mao, K., Han, W., Xu, F., ... & Sun, Y. (2019). AMPH-1 as a critical tumor suppressor that inhibits osteosarcoma progression. Cancer management and research, 11, 9913.

Lionello, V. M., Nicot, A. S., Sartori, M., Kretz, C., Kessler, P., Buono, S., ... & Cowling, B. S. (2019). Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice. Science translational medicine, 11(484).

Yang, H., Wan, Z., Huang, C., Yin, H., & Song, D. (2019). AMPH-1 is a tumor suppressor of lung cancer by inhibiting Ras-Raf-MEK-ERK signal pathway. Lasers in medical science, 34(3), 473-478.

Jiang, L., Ge, W., & Geng, J. (2019). miR-425 regulates cell proliferation, migration and apoptosis by targeting AMPH-1 in non-small-cell lung cancer. Pathology-Research and Practice, 215(12), 152705.

Chen, Y., Liu, J., Li, L., Xia, H., Lin, Z., & Zhong, T. (2018). AMPH-1 is critical for breast cancer progression. Journal of Cancer, 9(12), 2175.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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