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Mouse Anti-BCAM Recombinant Antibody (CBFYC-0574) (CBMAB-C0628-FY)

This product is mouse antibody that recognizes BCAM. The antibody CBFYC-0574 can be used for immunoassay techniques such as: WB.
See all BCAM antibodies

Summary

Host Animal
Mouse
Specificity
Human, Pig
Clone
CBFYC-0574
Antibody Isotype
IgG2b
Application
WB, FC, IF, ELISA, IHC

Basic Information

Immunogen
Human erythrocytes.
Host Species
Mouse
Specificity
Human, Pig
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Tris-Glycine
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Basal Cell Adhesion Molecule (Lutheran Blood Group)
Introduction
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
4059
UniProt ID
P50895
Alternative Names
Basal Cell Adhesion Molecule (Lutheran Blood Group); Basal Cell Adhesion Molecule (Lu And Au Blood Groups); B-CAM Cell Surface Glycoprotein; Auberger B Antigen; F8/G253 Antigen; MSK19; LU; Lutheran Blood Group (Auberger B Antigen Included); Lutheran Blood Group Variant LUGA
Function
Laminin alpha-5 receptor. May mediate intracellular signaling.
Biological Process
Cell adhesion Source: ProtInc
Cell-matrix adhesion Source: BHF-UCL
Signal transduction Source: ProtInc
Cellular Location
Membrane
Topology
Extracellular: 32-547 aa
Helical: 548-568 aa
Cytoplasmic: 569-628 aa
PTM
Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.

Wei, H., Cui, Y., Chen, Y., & Mu, S. (2020). The progress of abnormal expression of Lutheran blood group glycoprotein in cancers. Blood and Genomics, 4(1), 39-44.

Guadall, A., Cochet, S., Renaud, O., Colin, Y., Le Van Kim, C., de Brevern, A. G., & El Nemer, W. (2019). Dimerization and phosphorylation of Lutheran/basal cell adhesion molecule are critical for its function in cell migration on laminin. Journal of Biological Chemistry, 294(41), 14911-14921.

Reppin, F., Cochet, S., El Nemer, W., Fritz, G., & Schmidt, G. (2018). High affinity binding of Escherichia coli cytotoxic necrotizing factor 1 (CNF1) to Lu/BCAM adhesion glycoprotein. Toxins, 10(1), 3.

Azuma, M., Tsukada, T., Inagaki, T., Casmad, F., Jindatip, D., Tofrizal, A., ... & Yashiro, T. (2018). Immunohistochemical Study of the Laminin α5 Chain and Its Specific Receptor, Basal Cell Adhesion Molecule (BCAM), in both Fetal and Adult Rat Pituitary Glands. Acta histochemica et cytochemica, 51(5), 145-152.

Klei, T. R. L., de Back, D. Z., Asif, P. J., Verkuijlen, P. J. J. H., Veldthuis, M., Ligthart, P. C., ... & van Bruggen, R. (2018). Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging. Blood advances, 2(1), 14-24.

Miura, Y., Matsui, S., Miyata, N., Harada, K., Kikkawa, Y., Ohmuraya, M., ... & Tanaka, M. (2018). Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration. Elife, 7, e36572.

Chang, H. Y., Chang, H. M., Wu, T. J., Chaing, C. Y., Tzai, T. S., Cheng, H. L., ... & Liu, H. S. (2017). The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis. Journal of biomedical science, 24(1), 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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