BCAM

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Basal Cell Adhesion Molecule (Lutheran Blood Group)

Laminin alpha-5 receptor. May mediate intracellular signaling.

Cell adhesion Source: ProtInc
Cell-matrix adhesion Source: BHF-UCL
Signal transduction Source: ProtInc

Membrane

Extracellular: 32-547 aa
Helical: 548-568 aa
Cytoplasmic: 569-628 aa

Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin.