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  • Rabbit Anti-CCDC134 Recombinant Antibody (026)

Rabbit Anti-CCDC134 Recombinant Antibody (026) (CBMAB-C1688-LY)

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Datasheet
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Basic Information

Host Animal
Rabbit
Clone
026
Application
WB, IP
Immunogen
Recombinant Human CCDC134 protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IP1-4 μL/mg of lysate

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Coiled-Coil Domain Containing 134
Introduction
CCDC134 (Coiled-Coil Domain Containing 134) is a Protein Coding gene.
Entrez Gene ID
79879
UniProt ID
Q9H6E4
Alternative Names
Coiled-Coil Domain Containing 134;
Function
In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657).
Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657).
May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808).
May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Biological Process
Angiogenesis Source: Ensembl
Embryonic hemopoiesis Source: Ensembl
Embryonic liver development Source: Ensembl
Placenta development Source: Ensembl
Ventricular system development Source: Ensembl
Cellular Location
Endoplasmic reticulum; Cytoplasm; Secreted; Nucleus. Accumulates in the nucleus in response to UV irradiation (PubMed:22644376).
PTM
O-glycosylated, with additional sialic acid modifications.

Yin, S., Liao, Q., Wang, Y., Shi, Q., Xia, P., Yi, M., & Huang, J. (2021). Ccdc134 deficiency impairs cerebellar development and motor coordination. Genes, Brain and Behavior, 20(7), e12763.

Holick, M. F., Shirvani, A., & Charoenngam, N. (2021). Fetal Fractures in an Infant with Maternal Ehlers-Danlos Syndrome, CCDC134 Pathogenic Mutation and a Negative Genetic Test for Osteogenesis Imperfecta. Children, 8(6), 512.

Dubail, J., Brunelle, P., Baujat, G., Huber, C., Doyard, M., Michot, C., ... & Cormier‐Daire, V. (2020). Homozygous loss‐of‐function mutations in CCDC134 are responsible for a severe form of osteogenesis imperfecta. Journal of Bone and Mineral Research, 35(8), 1470-1480.

Xia, P., Gong, X., Xiao, L., Wang, Y., Zhang, T., Liao, Q., ... & Huang, J. (2018). CCDC134 ameliorated experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Brain, behavior, and immunity, 71, 158-168.

Yu, B., Zhang, T., Xia, P., Gong, X., Qiu, X., & Huang, J. (2018). CCDC134 serves a crucial role in embryonic development. International journal of molecular medicine, 41(1), 381-390.

Xia, P., Zhang, T., Gong, X., Xiao, L., Liao, Q., Qiu, X., & Huang, J. (2017). Amelioration of adjuvant-induced arthritis in CCDC134-overexpressing transgenic mice. Biochemical and biophysical research communications, 490(2), 111-116.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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