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Mouse Anti-CCDC134 Recombinant Antibody (CBYY-C1049) (CBMAB-C2486-YY)

This product is mouse antibody that recognizes CCDC134. The antibody CBYY-C1049 can be used for immunoassay techniques such as: ELISA
See all CCDC134 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1049
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recombinant Human CCDC134 protein. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CCDC134
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coiled-Coil Domain Containing 134
Entrez Gene ID
79879
UniProt ID
Q9H6E4
Alternative Names
C-C Motif Chemokine Ligand 22; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22; Chemokine (C-C Motif) Ligand 22; Macrophage-Derived Chemokine; CC Chemokine STCP-1; MDC(1-69); SCYA22; MDC; Stimulated T Cell Chemotactic Protein 1;
Function
In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657).
Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657).
May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808).
May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Biological Process
Angiogenesis Source: Ensembl
Embryonic hemopoiesis Source: Ensembl
Embryonic liver development Source: Ensembl
Placenta development Source: Ensembl
Ventricular system development Source: Ensembl
Cellular Location
Endoplasmic reticulum; Cytoplasm; Secreted; Nucleus. Accumulates in the nucleus in response to UV irradiation (PubMed:22644376).
PTM
O-glycosylated, with additional sialic acid modifications.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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