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CCDC134

CCDC134 (Coiled-Coil Domain Containing 134) is a Protein Coding gene.

Full Name

Coiled-Coil Domain Containing 134

Function

In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657).
Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657).
May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808).
May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

Biological Process

Angiogenesis Source: Ensembl
Embryonic hemopoiesis Source: Ensembl
Embryonic liver development Source: Ensembl
Placenta development Source: Ensembl
Ventricular system development Source: Ensembl

Cellular Location

Endoplasmic reticulum; Cytoplasm; Secreted; Nucleus. Accumulates in the nucleus in response to UV irradiation (PubMed:22644376).

PTM

O-glycosylated, with additional sialic acid modifications.

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Anti-CCDC134 antibodies

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Mouse Anti-CCDC134 Recombinant Antibody (CBYY-C1049) (CBMAB-C2486-YY)

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Target: CCDC134

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1049

Application*: E

Mouse Anti-CCDC134 Recombinant Antibody (CBYY-C0670) (CBMAB-C1984-YY)

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Target: CCDC134

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBYY-C0670

Application*: WB, IP, IF, E

Rat Anti-CCDC134 Recombinant Antibody (815606) (CBMAB-C8939-LY)

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Target: CCDC134

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 815606

Application*: WB

Mouse Anti-CCDC134 Recombinant Antibody (814208) (CBMAB-C8935-LY)

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Target: CCDC134

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 814208

Application*: WB

Rabbit Anti-CCDC134 Recombinant Antibody (026) (CBMAB-C1688-LY)

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Target: CCDC134

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 026

Application*: WB, IP

Mouse Anti-CCDC134 Recombinant Antibody (CBFYC-0909) (CBMAB-C0965-FY)

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Target: CCDC134

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-0909

Application*: WB, IP, IF, E

More Infomation

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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