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CCDC134

CCDC134 (Coiled-Coil Domain Containing 134) is a Protein Coding gene.
Full Name
Coiled-Coil Domain Containing 134
Function
In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657).
Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657).
May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808).
May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Biological Process
Angiogenesis Source: Ensembl
Embryonic hemopoiesis Source: Ensembl
Embryonic liver development Source: Ensembl
Placenta development Source: Ensembl
Ventricular system development Source: Ensembl
Cellular Location
Endoplasmic reticulum; Cytoplasm; Secreted; Nucleus. Accumulates in the nucleus in response to UV irradiation (PubMed:22644376).
PTM
O-glycosylated, with additional sialic acid modifications.
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Anti-CCDC134 antibodies

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Mouse Anti-CCDC134 Recombinant Antibody (CBYY-C1049) (CBMAB-C2486-YY)

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Target: CCDC134
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1049
Application*: E
Datasheet SDS

Mouse Anti-CCDC134 Recombinant Antibody (CBYY-C0670) (CBMAB-C1984-YY)

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Target: CCDC134
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0670
Application*: WB, IP, IF, E
Datasheet SDS

Rat Anti-CCDC134 Recombinant Antibody (815606) (CBMAB-C8939-LY)

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Target: CCDC134
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 815606
Application*: WB
Datasheet SDS

Mouse Anti-CCDC134 Recombinant Antibody (814208) (CBMAB-C8935-LY)

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Target: CCDC134
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 814208
Application*: WB
Datasheet SDS

Rabbit Anti-CCDC134 Recombinant Antibody (026) (CBMAB-C1688-LY)

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Target: CCDC134
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 026
Application*: WB, IP
Datasheet SDS

Mouse Anti-CCDC134 Recombinant Antibody (CBFYC-0909) (CBMAB-C0965-FY)

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Target: CCDC134
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0909
Application*: WB, IP, IF, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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